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Old 04-05-2008, 06:56 PM
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Default Cure For C-Diff and MRSA..

The following video is about a product called Phage. It will kill ANY antibiotic resistant bacteria, bar none. However, you will be surprised to hear what it is made from...
This video is well worth watching:

https://video.aol.com/video-detail/cd...ure/2170883548
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Old 04-05-2008, 09:10 PM
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pinballdoctor, very interesting video. bacteriophages are a very interesting subject. I posted about phages a year ago in relation to MRSA on HSI.

There are different companies working on developing phages (short for bacterophages), one company in Maryland.

about developing phages for MRSA:

https://www.phageinternational.com/pa...hylococcus.htm

https://www.phageinternational.com/clinics.htm
Quote:
Phage Therapy Center clinics specialize in two situations where bacteriophage therapy tends to be superior to standard and advanced treatments (including antibiotics) in the US and Western Europe:

1. Infections where circulation is poor, which makes it difficult to deliver the right concentration of antibiotics to the infected area. Such infections include, but are not limited to:

* Infected Wounds
* Osteomyelitis
* Diabetic Foot
* Tropic Ulcers
* Bed Sores
* Urinary Tract Infections
* Intestinal Infections
* Ear Infections, Otitis Media
* Sinus Infections
* Infections Complicated with Candida and other yeast / fungi
* Chronic Prostatitis and Associated Sexual Problems

2. Infections with bacteria that are resistant to standard or advanced antibiotics. Some but not all of these infections involve situations with poor circulation (such as those mentioned above), where insufficient antibiotic doses foster the growth of resistant bacteria. There are other cases, however, where poor circulation is not an important factor. Such cases can include:

* Methicillin-Resistant Staphylococcus aureus (MRSA) and other resistant strains of Staphylococcus bacteria
* Streptococcus
* E.coli
* Proteus
* Pseudomonas
* Several other bacterial strains that are emerging as significant challenges even to the most advanced antibiotics.

Contact:

Dr. Tengiz Chikvashvili
Phage Therapy Center Georgia
5 Chavchavadze Ave.
0179, Tbilisi, Georgia
Tel: (995-32) 48-4004
Fax: (995-32) 48-4005
E-mail: [email protected] (319 bytes)

For appointment information, send an email to [email protected] (319 bytes), or visit the Phage Therapy Center web site
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Old 04-05-2008, 09:15 PM
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more on bacteriophages:

https://www.intralytix.com/Intral_FAQ.htm

Quote:
What are phages and how do they kill bacteria?

Bacteriophages (phages) are viruses that infect bacteria. Typical phages have hollow heads (where the phage DNA or RNA is stored) and tunnel tails, the tips of which have the ability to bind to specific molecules on the surface of their target bacteria. The phage DNA is then injected through the phage tail into the host cell, where it directs the production of progeny phages [See Graphic], often >100 in 30 minutes. These "young" phages burst from the host cell (killing it) and infect more bacteria. Click here to see a simulation of the above-described process (Requires RealPlayer).
Phages are very specific. They can only infect their targeted bacteria, and they have no effect on any human, other animal, plant, insect, etc. cells.

How common are bacteriophages in nature?

Bacteriophages are the most common and ubiquitous organisms on Earth. Their total number is estimated to be approximately 1032. This value is equal to 100,000,000,000,000,000,000,000,000,000,000 phage particles.
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How safe are phage preparations developed for therapeutic applications?

Phages are very safe. They are the most common and ubiquitous organisms on this planet and humans consume them daily by drinking water, eating fresh foods, etc. Furthermore, phages have been used, since 1919, to treat various bacterial infections of humans and other animals. Large amounts of phages have been administered, without serious side-effects, to humans: (i) orally, in tablet or liquid formulations, (ii) rectally, (iii) locally (skin, eye, ear, nasal mucosa, etc.), in tampons, rinses and creams, (iv) as aerosols or intrapleural injections, and (v) intravenously. A few minor side-effects have been reported in patients undergoing phage therapy, and those that were seen seemed to be directly associated with the therapeutic process. For example, mild pain in the liver area (lasting several hours) was reported in one study conducted in Poland. The authors suggested that the response was related to extensive liberation of bacterial endotoxins from the phage-lysed bacteria. It should be mentioned that this side-effect also may occur during antibiotic therapy.
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Old 04-05-2008, 09:17 PM
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Quote:
Originally Posted by pinballdoctor View Post
The following video is about a product called Phage. It will kill ANY antibiotic resistant bacteria, bar none. However, you will be surprised to hear what it is made from...
This video is well worth watching:

https://video.aol.com/video-detail/cd...ure/2170883548
also.. Phages are very specific. They can only infect their targeted bacteria.

so, the phage for MRSA has to be developed to target MRSA.
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Old 04-06-2008, 02:12 AM
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Here are some articles with links on phage therapy. Phage therapy can be found in a clinic in Lubbock, Texas, called the Woundcare Center.

The amazing thing about phages was that this was not an uncommon treatment in the USA before the advent of antibiotics in the 1950's.


https://www.healthsalon.org/346/mrsa-...age-therapy-2/

https://www.healthsalon.org/100/effec...ngerous-drugs/
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Old 04-15-2008, 05:43 AM
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Using Viruses to Kill Bacteria

In the fight against infection, viruses may take up where antibiotics leave off.
By Jennifer Chu





In stitches:
Hospital sutures coated with a bacteria-fighting virus (shown above) effectively killed off 96 percent of an antibiotic-resistant bacteria in culture. Researchers used these same sutures to sew up bacterially infected wounds in live rats. The treated stitches prevented infection from flaring up, while rats with untreated sutures developed large sores and inflammation.
Credit: University of Strathclyde Hospitals are fertile ground for infectious bacteria, which can spread rapidly across countertops, stethoscopes, and catheters. These "superbugs" infect up to 1.2 million patients a year in the United States, according to a 2007 report from the Association for Professionals in Infection Control and Epidemiology, and they're quick to evolve defenses against even the most powerful antibiotics.


Now scientists in Scotland have come up with an alternative to antibiotics, which may effectively stop bacteria in its tracks. Janice Spencer and a team of researchers at the University of Strathclyde are developing nylon sutures coated with bacteriophages--viruses, found naturally in water, that eat bacteria while leaving human cells intact. New research by the Scottish team found that phage-coated sutures effectively stemmed infection in live rats.


Bacteriophages are not a recent discovery. During World War II, Russian doctors used cocktails of these viruses to treat soldiers infected with bacteria such as dysentery and gangrene. However, researchers soon turned their attention from bacteriophages to the rapidly rising field of antibiotics, developing new classes of antibiotics to combat ever-more-resistant strains of bacteria.
"Now we're coming to the end of the usefulness of antibiotics," says Spencer. "It takes time to get new classes of antibiotics onto the market, whereas bacteriophages can be easily isolated from environmental sources such as sewage water."


In water, these natural-born killers are extremely effective at eating up bacteria. The virus binds to bacteria and injects its DNA, replicating within its host until it reaches capacity, whereupon it bursts out, killing the bacteria in the process.
Obtaining bacteriophage-laden water samples is easy, says Spencer. The challenge is in keeping virus molecules active out of water. In dry environments, the virus's proteins tend to fall apart in a matter of hours, rendering them ineffective against bacteria. Spencer and her colleagues isolated bacteriophages from water samples and developed a novel method to keep them active.


The team chemically bound bacteriophages to microscopic polymer beads by first breaking the surface of the polymer. Then the researchers added a linker molecule to the polymer's surface, which in turn binds to bacteriophages and keeps them from falling apart. To test the virus's virulence, the team first made small incisions in live rats, then infected them with Methicillin-Resistant Staphylococcus Aureus (MRSA), one of the most resistant strains of bacteria found in hospitals. Half of the rats were stitched up with sutures that were coated with polymer-bound bacteriophages. The other rats were closed up with untreated sutures.
Spencer and her colleagues found that the wounds dressed with the treated sutures appeared to have no infection, while those stitched with regular sutures became inflamed, with large sores and "abundant pus."

The researchers further tested the bacteriophages' effectiveness, removing the treated sutures and placing them directly into a culture dish full of MRSA bacteria, obtained from patients in three different U.K. hospitals. They found that the virus remained active for up to three weeks, effectively killing off 96 percent of bacteria in culture.
Spencer says that, while bacteriophages will not completely replace antibiotics in fighting infection, these viruses have important advantages. "Antibiotics are broad-spectrum, and for certain bacterial strains, it's easier to use bacteriophages if you know exactly which bacterium is causing the infection," she says. "[With bacteriophages,] you can target one strain, and it wouldn't affect any other bacteria that may be protecting cells."
Synthetic biologist James Collins recently engineered viruses that kill off colonies of bacteria, called biofilms. Collins, a professor of biomedical engineering at Boston University, says that Spencer's technique clears many hurdles that have stymied bacteriophage use in the past. "It can be a surface-mounted bacteriophage, so instead of worrying about issues of ingesting a virus, by limiting application to the surface, they get around that concern," he says. "I suspect there might be interest in the Defense Department to use this early to treat infections in soldiers on the battlefield."


The Scottish team also hopes to incorporate microscopic beads of bacteriophages into sprays and creams, which, once dry, can remain active against bacterial infection for prolonged periods of time. The researchers are also exploring other methods of binding bacteriophages onto polymers, including a process known as corona discharge, which is commonly used to imprint ink onto plastic supermarket bags. The method involves a burst of high-voltage electricity, which acts to break up a polymer surface. Spencer says that this technique, patented by the University of Strathclyde, may improve the binding between polymer beads and bacteriophages.
In addition to therapeutic applications, bacteriophages may be useful in detecting bacterial infection, and the Scottish team has plans to investigate bacteriophages' diagnostic potential.


Spencer presented the group's findings at a recent meeting of the Society for General Microbiology, and since then, she has received queries from hospitals and pharmaceutical companies that have expressed interest in an antibiotic alternative. Currently, the team is in negotiations with Gangagen, a Canada-based biotechnology company that works on bacteriophage-based therapies.
https://www.technologyreview.com/Biotech/20566/page1/
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Old 04-15-2008, 07:32 AM
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Good fine Iggy. I wonder how long it will take for this technology to reach US shores.

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Old 04-15-2008, 03:40 PM
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Insulin and antibiotics were great discoveries, as they have saved many lives. However, nearly all antibiotics are useless against these "mutant" bacteria. Perhaps its time to go back to the "Phage" era, although I must admit I'm bothered with the idea of injecting a virus into my body. Just thinking about it gives me the creeps!
What if it kills the bacteria and keeps on going?...
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Old 04-15-2008, 05:48 PM
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I am pretty bothered by it too. They create these virus as they go along, sort of designer for the bacteria they are after. Lots of room there for a blunder I would think.

But you and me, we have MMS. I don't think we have to worry about it for ourselves and people close to us.

According to the following report we may have no choice


Food Sprays Fighting War on Bacteria: CBS News
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Old 04-04-2010, 11:41 AM
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I must say bacteriophages are one of the most amazing things I've ever seen. In that video they had little legs and would grab onto bacteria and inject them with a virus, creating thousands more.

Now I know what they are. I read a small blurb in Science News a few years ago about how phages were used to bust Alzheimer's plaques. The phages were delivered via the olfactory nerve, because they would otherwise be destroyed in the bloodstream. These nerves lead to the same areas in the brain affected by Alzheimer's (which also tells you that other things can travel the same route that may have contributed to the Alzheimer's such as toxins, heavy metals, mercury vapors from your fillings, etc). Once the phage enters the brain, it finds the plaque, injects it and it explodes. Then the immune system carries away the particles. This approach will have to be tested on humans and the potential is certainly there. And it may be that the plaque harbors some sort of bacteria that the phage enters? (my opinion)
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Old 04-04-2010, 03:30 PM
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The wound center in Lubbock, Texas is the only place in the US that actually does the work, that I know of anyway.
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