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Old 11-09-2007, 03:26 PM
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Default Lycopene and Colorectal Cancer

Quote:
Background: Higher circulating insulin-like growth factor I (IGF-I) concentrations have been related to a greater risk of cancer.

Lycopene intake is inversely associated with cancer risk, and experimental studies have shown that it may affect the IGF system, possibly through an effect on IGF-binding proteins (IGFBPs).


Design: We conducted a randomized, placebo-controlled, double-blinded crossover study in 40 men and 31 postmenopausal women with a family history of colorectal cancer, a personal history of colorectal adenoma, or both.

Results: Lycopene supplementation significantly (P = 0.01) increased serum IGFBP-1 concentrations in women (median relative difference between serum IGFBP-1 concentrations after lycopene supplementation and after placebo, 21.7%).

Serum IGFBP-2 concentrations were higher in both men and women after lycopene supplementation than after placebo, but to a lesser extent (mean relative difference 8.2%; 95% CI: 0.7%, 15.6% in men and 7.8%; 95% CI: –5.0%, 20.6% in women).


Total IGF-I, IGF-II, and IGFBP-3 concentrations were not significantly altered by lycopene supplementation.

Conclusions:
This is the first study known to show that lycopene supplementation may increase circulating IGFBP-1 and IGFBP-2 concentrations. Because of high interindividual variations in IGFBP-1 and IGFBP-2 effects, these results should be confirmed in larger randomized intervention studies.
https://www.ajcn.org/cgi/content/abstract/86/5/1456

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