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Old 09-06-2007, 07:43 PM
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Default Coffee and LDL Cholesterol

Coffee protects LDL cholesterol from oxidizing - which, in turn, protects your arteries from accumulating plaque.

Design: Ten healthy volunteers, after an overnight fast, drank 200 mL filtered coffee. Blood was drawn before and 30 and 60 min after drinking. Changes in LDL redox status were evaluated by the measure of LDL resistance to oxidative modification and the concentration of LDL(�), a mildly modified, electronegative LDL subfraction. Chlorogenic and phenolic acids concentration in LDL were measured by electrochemical HPLC.

Results: The resistance of LDL to oxidative modification increased significantly after coffee drinking, but the LDL(�) concentration did not increase. The concentration into LDL of conjugated forms of caffeic, p-coumaric, and ferulic acids increased significantly after coffee drinking.

Conclusion: Drinking 200 mL (1 cup) coffee induces an increase in the resistance of LDL to oxidative modification, probably as a result of the incorporation of coffee's phenolic acids into LDL.
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