Vitamin K May Combat Insulin Resistance

Harry Hirsute · � #1 � 08-14-2008, 06:28 PM

Quote:

Objective: Vitamin K has a potentially beneficial role on insulin resistance, but evidence is limited in humans. We tested the hypothesis that vitamin K supplementation for 36 months will improve insulin resistance in older men and women.

Research Design: This was an ancillary study of a 36-month, randomized, double-blind, controlled trial designed to assess the impact of supplementation with 500 mug/d of phylloquinone on bone loss. Study participants were older, non-diabetic men and women (n = 355; 60-80 y; 60% women).

The primary outcome of this study was insulin resistance, measured by the homeostasis model (HOMA-IR) assessed at 36 months. Fasting plasma insulin and glucose were examined as the secondary outcomes.

Results: The effect of 36-month vitamin K supplementation on HOMA-IR differed by sex (sex-by-treatment interaction: P = 0.02). HOMA-IR was statistically significantly lower at the 36-month visit among men in the supplement group vs. the men in the control group (P = 0.01) after adjustment for baseline HOMA-IR, BMI, and body weight change. There were no statistically significant differences in outcome measures between intervention groups in women.

Conclusions: Vitamin K supplementation for 36 months at doses attainable in the diet may reduce progression of insulin resistance in older men.

https://www.ncbi.nlm.nih.gov/pubmed/18697901

liverock · � #2 � 08-15-2008, 01:39 AM

I think perhaps it should be made clear that the study is talking about Vitamin K1( phylloquinone) and not vitamin K2.
The only problem with the validity of the study is the method used for testing, homeostasis,(HOMA-IR), which measures fasting glucose levels and has been found in other studies to be not as reliable as the more expensive method of testing glucose levels directly.

https://www.ncbi.nlm.nih.gov/pubmed/1...gdbfrom=pubmed

https://www.ncbi.nlm.nih.gov/pubmed/1...gdbfrom=pubmed

Despite this problem its good to know that vitamin K1 is just as important as vitamin K2 for artery health by helping to keep lower insulin resistance levels.

Harry Hirsute · � #3 � 08-15-2008, 09:51 AM

Thanks for adding some perspective to the abstract, Liverock.

At the moment, I get about 1 mg of K1 in my multi and an additional 200 mcg of K1 & K2 in a separate supplement. And, whatever I manage to extract from my diet - from broccoli, avocados, green tea, etc.

Hopefully, that's a pretty good mix.

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