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Old 09-15-2007, 03:57 PM
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Default Reishi May Lower Testosterone in Men

I'm not convinced that most men with BPH and/or prostate cancer would benefit from a lowering of their T levels.

I'm posting this because reishi is a pretty common supplement and it may be having an unexpected effect on some men, without them knowing it.

The anti-androgen effect of ganoderol B isolated from the fruiting body of Ganoderma lucidum.

Liu J, Shimizu K, Konishi F, Kumamoto S, Kondo R.

Department of Forest and Forest Products Science, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan.

The anti-androgenic activity of the ethanol extract of the fruiting body of Ganoderma lucidum has been previously reported. Ganoderol B with 5alpha-reductase inhibitory activity and the ability to bind to androgen receptor (AR) can inhibit androgen-induced LNCaP cell growth and suppress regrowth of the ventral prostate induced by testosterone in rats.

The down-regulation of AR signaling by ganoderol B provides an important mechanism for its anti-androgenic activity. In view of the fact that PSA (prostatic specific antigen, a well-accepted prognostic indicator of prostate cancer) is down-regulated, an important implication of this study is that ganoderol B intervention strategy aimed at toning down the amplitude of androgen signaling could be helpful in controlling morbidity of prostate cancer.

In conclusion, our result suggests that ganoderol B might be useful in prostate cancer and benign prostatic hyperplasia (BPH) therapy through suppressing the function of androgen and its receptor.
Reishi May Lower T Levels
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