12-07-2007, 07:37 PM
Join Date: Apr 2006
Location: Propecia, CA
Vitamin D Dosage in PM Women
Dose response to vitamin D supplementation among postmenopausal African American women
Sonia A Talwar, John F Aloia, Simcha Pollack and James K Yeh
From the Bone Mineral Research Center, Winthrop University Hospital, Mineola, NY
Background: Reports on the dose response to vitamin D are conflicting, and most data were derived from white men and women.
Objective: The objective was to determine the response of serum 25-hydroxyvitamin D [25(OH)D] to oral vitamin D3 supplementation in an African American population.
Design: Healthy black postmenopausal women (n = 208) participated in a vitamin D3 supplementation trial for a period of 3 y.
Analyses were done in the vitamin D supplementation arm (n = 104) to quantify the response in serum 25-hydroxyvitamin D concentrations at a steady state vitamin D input. The participants received 20 �g/d (800 IU) oral vitamin D3 for the initial 2 y and 50 �g/d (2000 IU) for the third year.
Results: Supplementation with 20 �g/d (800 IU/d) vitamin D3 raised the mean serum 25(OH)D concentration from a baseline of 46.9 � 20.6 nmol/L to 71.4 � 21.5 nmol/L at 3 mo.
The mean (�SD) concentration of serum 25(OH)D was 87.3 � 27.0 nmol/L 3 mo after supplementation increased to 50 �g/d (2000 IU/d).
All participants achieved a serum 25(OH)D concentration >35 nmol/L, 95% achieved a concentration >50 nmol/L, but only 60% achieved a concentration >75 nmol/L.
All patients had concentrations <153 nmol/L. On the basis of our findings, an algorithm for prescribing vitamin D so that patients reach optimal serum concentrations was developed.
The algorithm suggests a dose of 70 �g (2800 IU/d) for those with a concentration >45 nmol/L and a dose of 100 �g (4000 IU/d) for those with a concentration <45 nmol/L.
Conclusions: Supplementation with 50 �g/d (2000 IU/d) oral vitamin D3 is sufficient to raise serum 25-hydroxyvitamin D concentrations to >50 nmol/L in almost all postmenopausal African American women. However, higher doses were needed to achieve concentrations >75 nmol/L in many women in this population.
It could be that most African-American women require extra vitamin D because they don't synthesize it (vitamin D from sunlight exposure) as well as fair-skinned women.
Last edited by Harry Hirsute; 12-07-2007 at 07:52 PM.