Curcumin May Aid in Brain Regeneration

Harry Hirsute · � #1 � 03-27-2008, 09:00 AM

This is obviously very preliminary research. But it's still pretty-darn exciting if you ask me.

Quote:

J Biol Chem. 2008 Mar 24 [Epub ahead of print]

Curcumin stimulates proliferation of embryonic neural progenitor cells and neurogenesis in the adult hippocampus.

Kim SJ, Son TG, Park HR, Park M, Kim MS, Kim HS, Chung HY, Mattson MP, Lee J.

Pharmacy, Pusan National University, Busan 609-735.

Curcumin is a natural phenolic component of yellow curry spice, which is used in some cultures for the treatment of diseases associated with oxidative stress and inflammation.

Curcumin has been reported capable of preventing the death of neurons in animal models of neurodegenerative disorders, but its possible effects on developmental and adult neuroplasticity are unknown.

In the present study, we investigated the effects of curcumin on mouse multi-potent neural progenitor cells (NPC) and adult hippocampal neurogenesis. Curcumin exerted biphasic effects on cultured NPC - low concentrations stimulated cell proliferation, whereas high concentrations were cytotoxic.

Curcumin activated extracellular signal regulated kinases (ERKs) and p38 kinases, cellular signal transduction pathways known to be involved in the regulation of neuronal plasticity and stress responses. Inhibitors of ERKs and p38 kinases effectively blocked the mitogenic effect of curcumin in NPC.

Administration of curcumin to adult mice resulted in a significant increase in the number of newly-generated cells in the dentate gyrus of hippocampus, indicating that curcumin enhances adult hippocampal neurogenesis.

Our findings suggest that curcumin can stimulate developmental and adult hippocampal neurogenesis, a biological activity that may enhance neural plasticity and repair.

https://www.ncbi.nlm.nih.gov/pubmed/18362141

scorpiotiger · � #2 � 03-27-2008, 05:57 PM

I would think they should be able to see some consequence of this in the Indian population vs US? because curcumin is such a regular part of the Indian diet?

well.. think I will start making curry again.

for those of you that are into quick fix foods.. I would recommend this paste.
https://www.maesribrand.com/VacuumPack400.htm

my favorite is the panang curry paste. add it to coconut milk (did you hear that, Harry?), and pour over chicken that has been stir fried with ginger and garlic. very tasty.

the red curry paste is good too. the green curry, good.. but HOT!!

maesri makes one serving cans, so you can try different flavors easily. If you don't like it, you don't have a bunch left over. very nice.

here are some recipes for Thai curry:
https://www.grubshack.com/essays/thai-curry2.html

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