09-02-2008, 12:51 PM
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St. John's Wort vs. Prescription Antidepressant
Quote:
"Forty outpatients who suffered from depression according to the DSM-IV [Diagnostic and Statistical Manual of Mental Disorders, 4th Edition] diagnostic criteria were selected," reported principal investigator Christos Istikoglou, MD, Psychiatric Department, Asklepeion General Hospital of Voula, Athens, Greece, here on September 1, 2008.
Twenty patients received St. John's Wort at a dosage of 900 mg QD, whereas the remaining 20 participants were treated with duloxetine 60 30 mg QD.
In order to evaluate the severity of the depressive symptoms, patient assessments by means of the Hamilton Rating Scale for Depression (HAM-D) and the Montgomery-Asberg Depression Rating Scale (MADRS) were performed on days 1, 15, 30, and 45 as well as after 2 and 3 months.
"In the group of patients suffering from moderate depression, we did not find any statistically significant differences between the 2 treatment groups," Dr. Istikoglou said.
However, in the patients diagnosed with serious depression, treatment with St. John's Wort did not cause any substantial symptomatic improvement. "In this group, duloxetine contributed to a considerable symptom reduction according to the HAM-D and MADRS scales, proving the role that duloxetine plays in the treatment of serious depression," Dr. Istikoglou emphasised (P .01).
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