The surprising link between air pollution and Alzheimer’s disease


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Feb 20, 2017
new york
With new rules, the environmental regulations are expecting strict changes and monitoring. The latest research showed some strong proof of a link amid risk of dementia and air pollution.

A study that was published on Tuesday, suggested that breathing air is heavily polluted with automobile exhaust and other air pollutants such as fine particles, which increase the likelihood of rising dementia. And the women who have genetic variant APOE-e4 possess higher risk of having Alzheimer’s disease, if exposed to air pollution on daily basis.

A countrywide study traced the mental health of females in the age group of 65 to 79 years for at least 1 decade. It found that the women with genetic variant APOE-e4 were almost three times likelier to have dementia, if exposed to air pollution of high levels in comparison to non APOE-e4 carriers.
The study further suggested that elderly women who are carrier of genetic variant, if exposed to intense air pollution are more prone than to the ones who inhaled clean air to grow “global cognitive decline” – loss of retention and cognitive abilities short of dementia.

Although, scientist have checked health effects of air smog in lung illness, asthma and cardiovascular ailment, the effect of air toxins on brain condition has recently revealed. This study collects new understanding into the details of which key content of city smog harms the aging brain.

The news published in the magazine Translational Psychiatry, says that the research analyze a larger population of women in America, at mice in lab, and at tissues of brain in petri dishes. This is done to create a link between severe cognitive deterioration and the minute pollutant particles released by the vehicles, burning of biomass and power plants.

The biomedical research suggest that contact with high amount of minute air pollutants rises the symptoms of dementia such as loss of memory and disorientation. These symptoms shows amyloid beta protein clusters in brain and non-functional cells in the hippocampus of the brain – a vital center for memory development.

After using the air pollution standards that was formed by the Environmental Protection Agency, United States, the researcher have found noteworthy differences on all measures amid those who were exposed to clean air with those who inhaled polluted air that were considered unsafe.

When the mice labs were exposed to the breathing air collected from the ten freeways in Los Angeles showed concentrations of amyloidal protein in brain that was dense and likelier to grow clumps than compared to the air that was EPA satisfied before the year 2012.

With the development of mice with predisposition of dementia and its characteristics, the result showed huge differences amid pollution inhaling animals in comparison to those who inhaled clean air.

In the year 2011, a study indicated that people who lived closer to heavy traffic roads are at higher risk of experiencing dementia and stroke in comparison to those people who lived far away from traffic areas. A year after, researcher who led Alzheimer’s disease studies established that heavy air toxins trigger cell death, inflammation, and formation of amyloid protein in the mice brain.
The latest study extends those discoveries.
A new research work composed by geriatric and environmental health specialists at USC estimates that with the implementation of new air pollution rules in 2012 by the EPA, nearly 21% new cases of augmented cognitive decline and dementia could possibly have been credited to pollution in air.
All the studies indicate the possible legal implication to the scientific finding that females (and lab mice) who have genetic predisposition of having Alzheimer’s were highly sensitive to the effects of air pollution. In developing pollution criteria, the EPA is presently obliged to study their health influence on “susceptible populations”. The organisation also requires the practice of its regulatory authority in order to take actions to safeguard those populations.
Since the EPA has published the new criteria in 2012, there is a steady decline in air pollution. However, an environmental health expert at the USC’s School of Medicine and senior author of the study stated that it is yet not clear whether the present standards for air pollution are safe for elderly brains, or for those who are genetically predisposed to Alzheimer’s.
The New Administration has pointed that it will argument or significantly rewrite the old administration regulations that constricted release from power plants and laid harsher fuel efficiency ethics for vehicles in a way to limit climate change and minimize pollution in air. Established
Furthermore, “if the new administration is tyring to cut down the cost of disease treatment that includes dementia, then they must that be aware that reducing Clean Air Act rules will do the reverse,” said the authorities.