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Summary so far

Posted 08-30-2010 at 07:30 PM by jfh

I have decided to put this ongoing summary near the top, so you don't have to wade through my confirmation postings. I will try to keep up with it, each time I post.

The body maintains the intracellular cell's pH by using transport proteins located on the cell membrane and intracellular vesicles. The sodium bicarbonate co-transport is only one of these mechanisms.
The function of these proteins is closely linked to several hormone blood levels, systemic acid-base status, protein diet content as well as other factors. It has been recently demonstrated that the pHi (pH inside the cell) may be involved in numerous aspects of cell function, such as metabolism, apoptosis, malignancy and it is implicated in the pathogenesis of particular forms of renal stones (Dent's disease). Now, the question is, "Does the extracellular environment affect the inside?"

The environment, surrounding the tumor cells, which are normally acid, can be made alkaline with use of sodium chloride. The outside, of the tumor and its cells, is normally acid. The inside is in the neutral-to-alkaline range of pH. This outside environment keeps weak 'base' drugs from working properly. These drugs need to move the cell's inside to a higher pH (alkaline). It has been demonstrated that this environmental change can occur with tumour alkalinization following chronic ad libitum (oral, injection, IV) administration of NaHCO3 (sodium bicarbonate). All of this can enhance the use of chemotherapy.

The external pH of solid tumors is acidic as a consequence of increased metabolism of glucose and poor perfusion. Acid pH has been shown to stimulate tumor cell invasion and metastasis in vitro and in cells before tail vein injection in vivo. Oral NaHCO(3) selectively increased the pH of tumors and reduced the formation of spontaneous metastases in mouse models of metastatic breast cancer.
The weakness of this treatment regimen is that it was shown to significantly increase the extracellular pH, but not the intracellular pH. Bicarbonate treatment had mixed results, inhibiting the formation of metastases from PC3M prostate cancer cells, but not those of B16 melanoma. Seems so selective. Low pH was shown to increase the release of active cathepsin B. This is not a good thing. See my notes in my post, Bicarbonate inhibits spontaneous metastases. This is a plus for sodium bicarbonate treatment.

Proceed with caution. Enough of it can neutralize stomach acid, leading to unhealthy conditions. Of course, that can be corrected with other supplementation. Like TMG, trimethylglycine (unacidified betaine), or other methyl donors, B vitamins (B6, B12, folate), and zinc. Even apple cider vinegar can help. NaHCO(3) significantly increased the development of gastric cancer in a rat gastric stump model. Carbonate ions, which represent a major constituent of intestinal reflux into the stomach, increase the expression of ODC (ornithine decarboxylase) and thereby enhance cell proliferation in nontransformed mucosa, and consequently elevate the risk of gastric cancer. See my post on, "Proceed with caution" The carbonate ions come from the sodium bicarbonate. That is the CO3 part of the NaHCO3. I don't trust the test, as we don't know if bicarbonate was added to the food, causing neutralization of stomach acids. This is unhealthy. Common sense is required. Take it on an empty stomach.

It has been reported that a number of lipophilic statins cause apoptosis in various cells, but it is still not clear whether intracellular acidification is involved in statin-induced apoptosis. Bicarbonate can suppress this. Accordingly, bicarbonate suppressed statin-induced apoptosis. The strategy to combine statins with bicarbonate can lead to reduction in the chance of the severe adverse events including myopathy or rhabdmyolysis (generally refers to a disintegration in the muscle fibers).

Osmotic shock or osmotic stress is a sudden change in the solute concentration around a cell, causing a rapid change in the movement of water across its cell membrane. Under conditions of high concentrations of either salts, substrates or any solute in the supernatant, water is drawn out of the cells through osmosis. This also inhibits the transport of substrates and cofactors into the cell thus “shocking” the cell. Alternatively, at low concentrations of solutes, water enters the cell in large amounts, causing it to swell and either burst or undergo apoptosis.

Liquid ionic cesium chloride works by making cancer cells highly alkaline, typically 8.0 and above, thus making them so "sick" the immune system attacks and kills them.

Cesium chloride not only kills cancer cells indirectly, it immediately stops the metastasis of the cancer; can start shrinking tumor masses within weeks; and almost always stops the pain of cancer within 24 to 48 hours, depending on what is causing the pain.

The Cesium Chloride Protocol directly targets cancer cells. Normal cells do not ingest the cesium chloride. Cesium has been proven to get into cancer cells, when other nutrients cannot. I makes the cancer cells alkaline internally. I limits the intake of glucose into the cell, starving it. I neutralizes the lactic acid. It stops the fermentation process. Sodium bicarbonate can do some of the same things, but only for the outside of the cell. Maybe the molasses is the trick to get it inside the cell.

My post, "extracellular and intracellular pH on immune function cannot be ignored", indicates that it is important not to overlook the relationship of intracellular pH, extracellular pH, and the immune system. This one is hard to summarize, so go read it. Essentially, "The lowest pH values are found in those regions where tumor cells are growing adjacent to a basement membrane, causing necrotic foci and promoting tumor invasion." Meaning that the external environment should become more alkaline in order for the immune system to fight the invasion. That is part of what we were looking for. Right? But each cancer microenvironment is unique. For example, leukemic cells have a greater intracellular alkalinity. Increasing that alkalinity, will just make them multiply quickly. In the case of leukemia, neither the cesium nor the sodium bicarbonate protocol would work.

The sodium carbonate will neutralize the stomach acid, allowing the molasses or maple syrup to pass through will little digestion. This is a good method to get them both to the cancer cells. Cancer cells require more glucose than other normal cells. I don't know what that will do for some bad pathogens, like Candida Albicans. They like the alkaline environment and love sugar too. However, this recipe may kill the Candida, by increasing their intracellular pH, by the method of osmotic shock. See my post on binding the sodium bicarbonate with molasses for the recipe.

Now, all that's left, is to determine which cancers respond to this protocol. Not all do.

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