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intracellular pH in the regulation of cell function

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Posted 08-30-2010 at 05:15 PM by jfh

The article's use of sodium bicarbonate is in reference to that which is produced by the pancreas and kidneys.
The pancreas is primarily responsible for the production of enzymes and bicarbonate necessary for normal digestion of food. Bicarbonate is so important for protecting the kidneys that even the kidneys get into the act of producing bicarbonate.

The importance of intracellular pH in the regulation of cell function
[Article in Italian]
Capuano P, Capasso G.
Cattedra di Nefrologia, Seconda Universita' di Napoli, Napoli, Italy. [email protected]
Cell life is possible only if intracellular pH (pHi) oscillations are kept within a very narrow range. Measurement of pHi is therefore a very important parameter when examining cell and organ functions. Several methods have been used to monitor pHi; these include fluorescent dyes and pH sensitive electrodes. In addition, many instruments have been applied to the detection of pHi in living organs even at the level of single cells: NMR and confocal microscopy are just an example. Transport proteins located on the cell membrane and intracellular vesicles are responsible for maintaining the correct pHi. In renal tubular cells these include the sodium hydrogen exchanger (NHE), the sodium-dependent and independent chloride-bicarbonate exchanger (Cl--HCO3-), the sodium bicarbonate co-transport (Na+-HCO3-), the ATP-coupled proton pump (H+-ATPasi) and the ATP-dependent proton-potassium pump (H+-K+-ATPasi). All these carriers have been cloned and it is now clear that there are several isoforms with specific properties. The function of these proteins is closely linked to several hormone blood levels, systemic acid-base status, protein diet content as well as other factors. In addition, these carriers are not homogeneously distributed along the nephron and are sensitive to specific stimuli like interstitial osmolality and luminal fluid flow rate. Finally, it has been recently demonstrated that the pHi may be involved in numerous aspects of cell function, such as metabolism, apoptosis, malignancy and it is implicated in the pathogenesis of particular forms of renal stones (Dent's disease).
PMID: 12746799

Pasted from <https://www.ncbi.nlm.nih.gov/pubmed/12746799>

Cesium, also spelled Caesium, is a chemical element that has a 50% cure rate for cancer. It involves the manipulation of the intracellular pH.

How cesium works.

Technically, the cesium chloride does not directly kill the cancer cells. What is does is allow the immune system to kill the cancer cells. When you see a statement that cesium chloride does not kill cancer cells, that is technically correct.

Cesium has been proven to get into cancer cells, when other nutrients cannot.

Makes the cancer cells alkaline (Note: the BLOOD is NOT made alkaline, only the inside of the cancer cells)

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