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Introduction - sodium bicarbonate for use with cancer

Posted 08-30-2010 at 07:09 PM by jfh

I'm an amateur on a health quest, and want to share what I learn on my path.

I am trying to determine the value of sodium bicarbonate (baking soda) when one has cancer. I really want to know if the pH environment, alkaline or acid, has any effect on the curing, slowing, progression of cancer, or at least metastasis of existing cancer. Is low pH (acid) and high pH (alkaline -or base) to a cancer cell similar to hot and cold to humans? Is there something more than pH that affects the
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Definitions

Posted 08-30-2010 at 06:11 PM by jfh

Definitions.
I'm just an amateur, so I don't understand much in these medical journals. So, I need definitions. I'll add to these a I go.

apoptosis (ˌæpəpˈtəʊsɪs)
biology Also called: programmed cell death the programmed death of some of an organism's cells as part of its natural growth and development

in vivo
[in vee-voh]
(of biological processes or experiments) occurring or carried out in the living organism
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Summary so far

Posted 08-30-2010 at 05:30 PM by jfh

I have decided to put this ongoing summary near the top, so you don't have to wade through my confirmation postings. I will try to keep up with it, each time I post.

The body maintains the intracellular cell's pH by using transport proteins located on the cell membrane and intracellular vesicles. The sodium bicarbonate co-transport is only one of these mechanisms.
The function of these proteins is closely linked to several hormone blood levels, systemic acid-base status,...
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intracellular pH in the regulation of cell function

Posted 08-30-2010 at 05:15 PM by jfh

The article's use of sodium bicarbonate is in reference to that which is produced by the pancreas and kidneys.
The pancreas is primarily responsible for the production of enzymes and bicarbonate necessary for normal digestion of food. Bicarbonate is so important for protecting the kidneys that even the kidneys get into the act of producing bicarbonate.


Quote:
The importance of intracellular pH in the regulation of cell function
[Article in Italian]
Capuano P,
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pH and chemotherapy

Posted 08-30-2010 at 04:21 PM by jfh

This article indicates that the environment, surrounding the tumor cells, which are normally acid, can be made alkaline. It does not indicate how the sodium bicarbonate gets there to do this function. I'm going to assume that it is orally.


Quote:
pH and chemotherapy
Raghunand N, Gillies RJ.
University of Arizona Health Sciences Center, Cancer Center Division, Tucson 85724-5024, USA.
Abstract
In vivo pH measurements by magnetic resonance spectroscopy
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Bicarbonate inhibits spontaneous metastases

Posted 08-30-2010 at 03:26 PM by jfh

Quote:
Bicarbonate increases tumor pH and inhibits spontaneous metastases.
Robey IF, Baggett BK, Kirkpatrick ND, Roe DJ, Dosescu J, Sloane BF, Hashim AI, Morse DL, Raghunand N, Gatenby RA, Gillies RJ.
Arizona Cancer Center, University of Arizona, Tucson, Arizona, USA.
Abstract
The external pH of solid tumors is acidic as a consequence of increased metabolism of glucose and poor perfusion. Acid pH has been shown to stimulate tumor cell invasion and metastasis in
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Proceed with caution

Posted 08-30-2010 at 01:32 PM by jfh

Proceed with caution.

It appears that a long duration of taking sodium bicarbonate could cause problems. At least, in rats. I figure that it is not good to keep the stomach acids low.
But notice that they do not say whether they added the bicarbonate to the food. That would be very bad over the duration. The stomach acids would be neutralized. Must have common sense. Cautionary guidance would be that you should not take sodium bicarbonate with food. It would not...
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Bicarbonate suppresses statin-induced apoptosis

Posted 08-30-2010 at 12:50 PM by jfh



Preventive effects of bicarbonate on cerivastatin-induced apoptosis.
Kobayashi M, Kaido F, Kagawa T, Itagaki S, Hirano T, Iseki K.
Department of Clinical Pharmaceutics & Therapeutics, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-12-jo, Nishi-6-chome, Kita-ku, Sapporo 060-0812, Japan.
Abstract
Although HMG-CoA reductase inhibitors such as statins are the most widely used cholesterol-lowering agents, there is a risk of myopathy...
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