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Old 03-09-2008, 03:18 PM
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Default Glucosamine Sulphate May Reduce Need for Knee Replacment

In a study involving 275 patients with osteoarthritis of the knee, supplementation with glucosamine sulfate for at least 12 months was found to reduce the likelihood of requiring a total joint replacement over a 5 year period.

Subjects were selected from 2 previous studies in which they either received glucosamine sulfate (n=144) or a placebo (n=131) for at least 12 months, and up to 3 years. Patients were followed up with for approximately 5 years from the time the trials were terminated and the treatment was discontinued.

Results found twice as many total knee replacement surgeries had occurred in the placebo group (14.5% of the group, 19 out of 131 subjects), as compared to the group of subjects who had formerly received glucosamine sulfate (6.3% of the group, 9 out of 144 subjects).

The relative risk of total knee joint replacement was found to be 0.43 among subjects who formerly received glucosamine sulfate. These results were confirmed by the Kaplan Meier/Log-Rank test survival analysis, which found a significantly decreased cumulative incidence of total knee replacements in patients who had received glucosamine sulfate.

Furthermore, results of a pharmaco-economic analysis of a subgroup of subjects suggested that subjects who had previously received glucosamine sulfate had less use of medications used to alleviate symptoms and less use of other health resources in general.

The authors conclude, "Treatment of knee OA with glucosamine sulphate for at least 12 months and up to 3 years may prevent total joint replacement in an average follow-up of 5 years after drug discontinuation."

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