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Old 03-09-2008, 03:11 PM
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Default Brussels Sprouts May Prevent DNA Damage

In an intervention trial involving 8 human subjects, consumption of Brussels sprouts (300 g/p/d) was found to inhibit sulfotransferases and protect against PhIP and oxidative DNA damage. Previous epidemiological studies have found consumption of Brussels sprouts to protect against cancer.

The authors of this study aimed to investigate whether the chemopreventive effects of Brussels sprouts were due to Brussels sprouts possible protection against DNA damage. Subjects consumed Brussels sprouts (300 g/p/d) after which the effects on DNA-stability were monitored in lymphocytes using commet assay.

Results showed a 97% reduction in DNA-migration induced by the heterocyclic aromatic amine 3-amino-l-methyl-6-phenyl-imidazo-[4,5-b]pyridine (PhIP) after consumption of Brussels sprouts. The authors hypothesize that this may be due to inhibition of sulfotransferase 1A1 which plays a key role in activation of PhIP.

Furthermore, after consumption of Brussels sprouts, endogenous formation of oxidized bases was decreased, DNA damage caused by hydrogen peroxide was 39% lower, and serum vitamin C levels were 37% higher.

The authors conclude, "Our study shows for the first time that sprout consumption leads to inhibition of sulfotransferases in humans and to protection against PhIP and oxidative DNA-damage."

a healthy Brussels Sprout recipe:


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