Isoleucine Prevents Liver Metastases Via Antiangiogenesis

Iggy Dalrymple · � #1 � 03-14-2008, 05:44 AM

Quote:

Isoleucine, an essential amino acid, prevents liver metastases of colon cancer by antiangiogenesis.
Murata K, Moriyama M.

The First Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie, Japan.

In spite of recent advances in the treatment of colon cancer, multiple liver metastases of colon cancer are still difficult to treat. Some chemotherapeutic regimens have been reported to be efficient, but there is a high risk of side effects associated with these. Here, we show that isoleucine, an essential amino acid, prevents liver metastases in a mouse colon cancer metastatic model. Because isoleucine is a strong inducer of beta-defensin, we first hypothesized that it prevented liver metastases via the accumulation of dendritic cells or memory T cells through up-regulation of beta-defensin. However, neither beta-defensin nor immunologic responses were induced by isoleucine in both mouse livers and spleens. Furthermore, isoleucine prevented liver metastasis in nude mice, which lack T cells and natural killer T cells. Finally, we discovered a novel mechanism of isoleucine: down-regulation of angiogenesis via inhibition of vascular endothelial growth factor, partially through the mammalian target of the rapamycin pathway, independent of hypoxia-inducible factor 1-alpha. Importantly, isoleucine is safe for administration to humans because it does not affect cell viability. Isoleucine could be a novel prophylactic drug for the prevention of liver metastases of colon cancer.

PMID: 17409434 [PubMed - indexed for MEDLINE]
https://preview.tinyurl.com/yv3jdk

More from Dr Steve Martin at Grouppe Kurosawa.
https://grouppekurosawa.com/blog/index.htm

Harry Hirsute · � #2 � 03-14-2008, 08:30 AM

I just read about this too. Sounds promising.

Iggy Dalrymple · � #3 � 03-14-2008, 12:43 PM

There's a very smart technical health writer named Sheila that ridicules every post I make at The Motley Fool that refers to Grouppe Kurosawa's findings.

I agree with her that Dr Steve Martin is a pompous arrogant guy that over-hypes most of his recommendations. Nevertheless, Dr Steve serves a useful purpose in digging up all this stuff. Sure, isoleucine hasn't been proven to reverse colon cancer in humans, but what's the downside? It's cheap, safe and offers more hope than chemo/radiation.

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