09-29-2008, 09:00 PM
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Lecturer
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Join Date: Apr 2006
Location: Propecia, CA
Posts: 1,851
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Ellagic Acid - How it Fights Cancer
Quote:
September 26, 2008
Ellagic acid’s anticancer mechanisms identified
Ellagic acid, a polyphenolic compound found in raspberries, strawberries, and pomegranates, appears to exert its anticancer benefit by dramatically reducing cell proliferation as well as by promoting programmed cell death (apoptosis), according to a report published in the June 21, 2008 issue of the World Journal of Gastroenterology.
The compound has previously been demonstrated to have antioxidant and antifibrosis properties, in addition to showing effects against several cancers, yet its mechanisms of action had not been defined.
Mouad Edderkaoui and colleagues at the West Los Angeles Veterans Administration Healthcare Center administered three concentrations of ellagic acid to two human pancreatic cancer cell lines. Pancreatic cancer is known to be resistant to standard forms of treatment.
Apoptosis, cell proliferation, and other factors were measured after 48 hours of the cells' exposure to ellagic acid. Ellagic acid was found to dose-dependently increase apoptosis in the first pancreatic cancer cell line. Significant ellagic acid-induced apoptosis was also observed in the second cell line, although the association was not dose-dependent. Cell proliferation was reduced 20 fold by the highest concentration of ellagic acid in the first cell line, and was dose-dependently reduced, although to a lesser extent, in the second line.
The researchers found that ellagic acid induced apoptosis in both cell lines by reducing the binding activity of the prosurvival transcription factor nuclear factor-kappa beta. "Our results . . . indicate that ellagic acid is a powerful phenolic compound with proapoptotic and antiproliferation effects in cancer cells," the authors conclude.
"There is an increasing interest in the use of natural products for cancer treatments," they write. "Our results suggest a potential therapeutic role for ellagic acid in the treatment of pancreatic cancer.
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https://www.lef.org/whatshot/2008_09....sms-identified
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