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\r\n \r\n The Cholesterol hypothesis: Time for the obituary?
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\r\nGood to see that researchers are beginning to understand that statins don\'t help prevent heart disease and may be counter-productive.
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\r\nHowever the history of the Lipid Hypothesis as detailed here is not exactly an accurate reflection of what actually happened as Denise Minger details here The Truth About Ancel Keys: We�ve All Got It Wrong\r\n
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\r\n \r\n Serum cholesterol levels and survival after rtPA treatment in acute stroke
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\r\n \r\n Background: 
\nAccording to the reverse epidemiology hypothesis, high cholesterol levels might be protective and associated with greater survival rates under certain conditions.
\nIn stroke patients, a clear correlation between lipid levels and mortality after ischaemic and hemorrhagic strokes has been demonstrated.
\nThe aim of this study was to analyze the impact of lipid levels on 3-month mortality in patients with ischaemic stroke (IS) homogeneously treated with intravenous rtPA and admitted to a monitored acute stroke unit.
\nMethods: 
\nRetrospective analysis of a prospective cohort of 220 patients with an IS treated with rtPA within the first 4.5 h in a single tertiary hospital from January 2005 to August 2010.
\n Results: 
\n Mortality at 3 months was 15.0%.
\nUnivariate analysis showed that age, NIHSS at admission, heart failure, and atrial fibrillation were directly related to 3-month mortality; cholesterol, triglycerides, and low density lipoprotein were inversely associated.
\n The death rate by cholesterol level was
\n 5.5% for the highest tertile (>192 mg/dl),
\n13.7% for the middle (192-155 mg/dl), and
\n25.7% for the lowest (<155 mg/dl), P = 0.003.
\nMultivariate analysis showed that amongst the lipid determinations, only cholesterol [OR: 0.985 (95% CI: 0.972-0.998), P = 0.021] was inversely associated with 3-month mortality.
\n The \'protective\' effect of cholesterol was independent of stroke severity and remained significant in non-lacunar strokes.
\n Conclusions: 
\n Survival of stroke patients receiving current, most effective medical treatment is related to blood cholesterol levels, with an inverse relationship between cholesterol and mortality.
\nThe mechanism of this apparently paradoxical situation remains unexplained but merits further research.\r\n \r\n
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So only LOWER your CHOLESTEROL if you want to INCREASE your risk of DYING.\r\n
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Default The Cholesterol hypothesis: Time for the obituary?
The Cholesterol hypothesis: Time for the obituary?

Good to see that researchers are beginning to understand that statins don't help prevent heart disease and may be counter-productive.

However the history of the Lipid Hypothesis as detailed here is not exactly an accurate reflection of what actually happened as Denise Minger details here The Truth About Ancel Keys: We�ve All Got It Wrong
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