Reactivation of the p53 gene destroys cancer.

Iggy Dalrymple · ï¿½ #1 ï¿½ 01-24-2007, 02:31 PM

Quote:

To reactivate p53, Lowe and his colleagues used a genetic technique they had developed to induce an aggressive form of liver cancer in mice. Although they had inactivated p53 in the mice, they genetically engineered the mice so that they could reverse p53 inactivation by giving the animals the antibiotic doxycycline. They suppressed p53 protein levels by using RNA interference (RNAi) that had been modified so that RNAi could be switched off by the antibiotic. The RNA interference technology was developed in collaboration with HHMI investigator Gregory Hannon at Cold Spring Harbor Laboratory.

When the researchers reactivated p53 in the mice they found that the liver tumors completely disappeared. ï¿½This was quite surprising,ï¿½ said Lowe. ï¿½We were working with a very advanced, aggressive tumor, but when we reestablished p53, not only did it stop growing, it went away. https://www.hhmi.org//news/jackslowe20070124.html

Mad Scientest · ï¿½ #2 ï¿½ 01-24-2007, 06:26 PM

Ah finally some good cancer news.
Particularly if you are a mouse.

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