Gail Prins, professor of urology at the UIC College of Medicine and lead investigator on the grant, and her colleague, Shuk-Mei Ho, professor and chair of environmental health at the University of Cincinnati, established in earlier studies in animals that perinatal exposure to BPA at very low doses results in increased sensitivity to estrogen as the male animal ages and an increased risk of developing prostate cancer.
BPA is a key chemical in the production of polycarbonate plastic and epoxy resins and is found in products ranging from baby bottles to tin can linings. BPA may break down and leach into food or beverages when it is heated. More than a billion pounds of BPA is produced in the United States each year. The U.S. Centers for Disease Control and Prevention has found BPA in 92 percent of Americans age six or older.
We may not know all the ways in which the chemical bisphenol-A (BPA) affects our health, but we can be assured that we're exposed to it frequently � BPA is in many plastic products and lines nearly all food and beverage cans.
Exposure to BPA, an endocrine-disrupting compound that mimics the body's hormones, has been linked to heart disease, diabetes and obesity, and to potential problems during development in fetuses and young children. In Canada and Europe, the chemical has been banned outright from baby bottles, and while many manufacturers have removed BPA from baby products in the U.S., it hasn't been regulated yet by the government.
Researchers led by Jenny Carwile, a doctoral student in epidemiology at the Harvard School of Public Health, sought to figure out just how much BPA you get from eating food from cans. Carwile and her colleagues recruited 75 fellow students and staff members to participate in the study. Half of the participants were asked eat one 12-oz. can of vegetarian soup each day for five days, while the other group ate soup made from fresh ingredients. Then, after a two-day interim of no canned soup, the two groups switched roles for another five days. This way, says Carwile, she could be sure that whatever else the participants were eating during the two-week study wouldn't affect their BPA levels, since the only thing that changed was the source of their soup.
To measure levels of BPA, the researchers asked all the participants to give urine samples after each soup-eating period. Carwile found that in the fresh-soup group, average levels of urinary BPA were about 1.1 micrograms per liter, roughly equivalent to what's seen in the average American adult. After five days of eating canned soup, however, those levels rose to 20.8 mcg per liter, a more than 1,000% increase.
The study � the first to measure how much BPA is absorbed by eating canned food � found some of the highest recorded levels of BPA in urine outside of manufacturing facilities where BPA is used. "We were surprised," says Carwile. "Other studies have quantified the amount of BPA in canned food itself, so we were expecting a modest association. But this is really big."
Although the study, published in the Journal of the American Medical Association, looked only at canned soup, the results likely apply to other canned foods and beverages as well.
The researchers did not explore the health effects of the spike in BPA levels or how quickly those levels may return to normal. Other studies have noted that BPA levels do fluctuate depending on people's exposure to the chemical, but it's not clear yet whether repeated spikes of BPA concentrations are particularly harmful or not. "We see an increased amount of BPA in urine. We don't know how long that lasts, and we don't know the effect of a fluctuating BPA level on health outcomes. But the results definitely deserve further study," says Carwile.
According to the Centers for Disease Control and Prevention, 93% of Americans have a detectable amount of BPA in their bodies. BPA comes not only from food and drink in cans, but also those packaged in polycarbonate plastic. The chemical is also found on thermal register receipts, which people receive at checkout at nearly every retailer.
The Food and Drug Administration says the small amount of BPA exposure we typically get doesn't appear to be toxic, but notes that recent studies have led to "some concern about the potential effects of BPA on the brain, behavior, and prostate gland in fetuses, infants and young children." A growing number of studies also links BPA exposure to changes in liver and heart function, and to detrimental effects on insulin levels. In a study involving a U.S. government health database, for example, British researchers reported that people with the highest levels of BPA in their urine were twice as likely to have heart disease or diabetes as those with lower levels.
The FDA is currently conducting further studies on the effects of BPA exposure and supporting other research seeking alternative ways to manufacture food and beverage cans without BPA in the lining. In the meantime, the agency is continually urging manufacturers to stop using BPA in baby bottles and feeding cups.
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- Jim "The most powerful force ever known on this planet is human cooperation � a force for construction and destruction.� (Jonathan Haidt)
perinatal exposure to BPA
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