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Old 04-13-2008, 01:19 PM
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Default How Calcium and Vitamin May Combat Colon Cancer

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Vitamin D and calcium influence cell death in the colon, researchers find

Researchers at Emory University are learning how vitamins and minerals in the diet can stimulate or prevent the appearance of colon cancer.

Emory investigators will present their findings on biological markers that could influence colon cancer risk in three abstracts at the American Association for Cancer Research meeting in San Diego.

In a clinical study of 92 patients, supplementing diet with calcium and vitamin D appeared to increase the levels of a protein called Bax that controls programmed cell death in the colon. More Bax might be pushing pre-cancerous cells into programmed cell death, says Emory researcher Veronika Fedirko, who will present her team's results (abstract 464).

Previous studies have shown that calcium and vitamin D tend to reduce colon cancer risk.

"We were pleased that the effects of calcium and vitamin D were visible enough in this small study to be significant and reportable," Fedirko says. "We will have to fully evaluate each marker's strength as we accumulate more data."

The studies of colorectal biopsy samples are part of a larger effort to identify a portfolio of measurements that together can gauge someone's risk of getting colon cancer, says Roberd Bostick, MD, MPH, professor of epidemiology at Emory's Rollins School of Public Health.

"We want to have the equivalent of measuring cholesterol or high blood pressure, but for colon cancer instead of heart disease," Bostick says. "These measurements will describe the climate of risk in the colon rather than spotting individual tumors or cells that may become tumors."

More about Bostick's plans for developing non-invasive blood or urine tests for colon cancer risk is available in an Emory Health Sciences Magazine article: https://whsc.emory.edu/_pubs/hsc/wint...our_finger.pdf

Another abstract from Bostick and his colleagues (565) demonstrates in a 200-patient case-control study that high levels of calcium and vitamin D together are associated with increased levels of E-cadherin, which moderates colon cells' movement and proliferation.

A third abstract on the same case-control study (5504) shows that high levels of iron in the diet are linked to low levels of APC, a protein whose absence in colon cancer cells leads to their runaway growth.

Bostick and his colleagues are participating in a ten-year multi-center study of the effects of increased vitamin D and calcium and biomarker-guided treatment of colon cancer recurrence. The study involves almost 2,500 people nationwide who have regular colonoscopies.
###

The Bostick team's research is funded by the National Cancer Institute and the Wilson and Anne Franklin Foundation.
https://www.eurekalert.org/pub_releas...-vda040908.php
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Old 01-22-2010, 07:04 AM
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Vitamin D May Lower Colon Cancer Risk

Study Shows Higher Blood Levels of Vitamin D Linked to Reduced Risk of Colorectal Cancer
By Kelli Miller Stacy
WebMD Health News
Reviewed by Brunilda Nazario, MD



Jan. 21, 2010 -- Soaking in more sunlight and drinking more dairy may help you ward off colon cancer.

Researchers in Europe have found that people with abundant levels of vitamin D -- the so-called sunshine vitamin -- have a much lower risk of colon cancer. The findings add to a growing body of evidence that suggest vitamin D may have the power to help prevent colon cancer and possibly even improve survival in those who have the disease.

The body makes vitamin D after the skin absorbs some of the sun's rays. You can also get vitamin D by consuming certain foods and beverages, such as milk and cereal, which have been fortified with the vitamin, but few foods naturally contain it.

For the current study, researchers looked at the link between blood levels of vitamin D as well as dietary vitamin D and calcium, and who was at risk for colorectal cancer. They based their findings on information from the European Prospective Investigation into Cancer Study (EPIC), a study of more than 520,000 people from 10 Western European countries. The study participants gave blood samples and completed detailed diet and lifestyle questionnaires between 1992 and 1998.

During the follow-up period, 1,248 patients were diagnosed with colorectal cancer. Researchers compared their lifestyle and diet backgrounds to the same number of healthy patients. They discovered that those with the highest blood levels of vitamin D had a nearly 40% decrease in colorectal cancer risk than those with the lowest levels.

However, the best way to boost your vitamin D level may be a matter of debate. As vitamin D's potential health benefits become more widely advertised, more people may advocate supplementation. However, the researchers say it's unclear if supplements are better at increasing blood levels of vitamin D than a balanced diet and moderate exposure to outdoor sunlight. They caution that the long-term effects of taking large doses of vitamin D supplements have not been well studied.

"Our findings suggest that the potential cancer risk benefits of higher vitamin D levels should be balanced with caution for the toxic potential," they write in today's online version of BMJ. "Before any public health recommendations can be made for vitamin D supplementation, new randomized trials are needed to test the hypothesis that increases in [blood levels of vitamin D] are effective in reducing colorectal cancer risk without inducing serious adverse events."

Colorectal cancer is the third most common cancer in men and women in the U.S., according to the American Cancer Society
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Old 01-22-2010, 08:27 AM
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Originally Posted by liverock View Post
They caution that the long-term effects of taking large doses of vitamin D supplements have not been well studied.

"Our findings suggest that the potential cancer risk benefits of higher vitamin D levels should be balanced with caution for the toxic potential," they write in today's online version of BMJ. "Before any public health recommendations can be made for vitamin D supplementation, new randomized trials are needed to test the hypothesis that increases in [blood levels of vitamin D] are effective in reducing colorectal cancer risk without inducing serious adverse events."
Thanks for the article liverock! Are there any conditions now that make people poor candidates for vitamin D3 supplementation? Is it safe for everyone, at every age? Is there any damage to the body if large amounts of D are taken, like over 10,000 IUs per day?
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Old 01-22-2010, 10:37 AM
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Checkout this thread for contraindications and safe levels.

/f52/3826-vitamin-d-may-prevent-fractures-older-adults.html

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