Specifically, the homeostasis of lipid metabolism collapses during acute-phase inflammatory response triggered by a pathogen, trauma, or stress, starting a feedback loop of increased oxidative stress, inflammatory response, and proliferation of cytoxic foam cells that cross the blood brain barrier and both catabolize myelin and prevent remyelination.
Interesting. This would make the possible triggers of MS similar to the possible triggers of ME/CFS. Trigger doesn't mean cause, though, and all the events and onslaughts to the body have to be considered as possible causes which make it susceptible to a trigger--low nutrition including Vitamin D, Vaccines, Mercury, toxins, others, all of these and more combined, something else? Keep looking and studying.
You can't avoid pathogens, trauma or stress in many cases. What is involved in stopping the causes so the trigger doesn't trigger anything?
It also doesn't mean that immunity is not involved. ME/CFS is not an autoimmune disease but is has an autoimmune aspect. The immune system deregulation may be the effect, not the cause, but it could still be involved in the cause.
More importantly, if a person gets MS, how do you cure it? How do you fix the immune system--that's a biggie!, the myelin, stop the possible cytokine storm or the inflammation or whatever's involved, and all the damage done to the body via the feedback loop, or the cascade of reactions and damage? We have to know that, what is causing what along the way and how to stop it, fix it break the loop, unblock the blocks, not just the absolute one cause, if there is only one. They keep looking for one cause to these diseases. Maybe the lipid metabolism collapsing is an effect of something else.
I wish the doctors and scientistics could get together and pool their knowledge instead of working alone with their teams and saying, I found it, when all they did was touch one part of the elephant.