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\nDiet Soda Intake and Risk of Incident Metabolic Syndrome and Type 2 Diabetes in the Multi-Ethnic Study of Atherosclerosis.
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\nNettleton JA, Lutsey PL, Wang Y, Lima JA, Michos ED, Jacobs DR Jr.
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\nFrom the Division of Epidemiology, University of Texas Health Sciences Center, Houston, TX, the.
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\nObjectives: We determined associations between diet soda consumption and risk of incident MetSyn, its components, and type 2 diabetes in the Multi-Ethnic Study of Atherosclerosis.
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\nResearch Design & Methods: Diet soda consumption was assessed by food frequency questionnaire at baseline (2000-02). Incident type 2 diabetes was identified at three follow-up exams (2002-03, 2004-05, 2005-07) as fasting glucose >126 mg/dL, self-reported type 2 diabetes, or use of diabetes medication. MetSyn (and components) were defined by National Cholesterol Education Program Adult Treatment Panel 3 criteria. Hazard ratios (HR with [95% CI]) for type 2 diabetes, Met Syn, and MetSyn components, were estimated adjusting for demographic, lifestyle, and dietary confounders.
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\nResults: At least daily consumption of diet soda was associated with a 36% greater relative risk of incident MetSyn and a 67% greater relative risk of incident type 2 diabetes compared to non-consumption (1.36 [1.11, 1.66] for MetSyn; 1.67 [1.27, 2.20] for type 2 diabetes). Of MetSyn components, only high waist circumference (men: >/=102 cm; women: >/=88 cm) and high fasting glucose (>/=100 mg/dL) were prospectively associated with diet soda consumption.
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\nAssociations between diet soda consumption and type 2 diabetes were independent of baseline measures of adiposity or changes in these measures, whereas associations between diet soda and MetSyn were not independent of these factors.
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\nConclusions: Although these observational data cannot establish causality, consumption of diet soda at least daily was associated with significantly greater risks of select incident MetSyn components and type 2 diabetes.\r\n \r\n | \r\n \r\n \r\n \r\n \r\n <!-' + '- controls -' + '->\r\n \r\n \r\n \r\n  \r\n \r\n \r\n \r\n \r\n \r\n \r\n \r\n \r\n \r\n \r\n <!-' + '- / controls -' + '->\r\n | \r\n
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