Results: Cognitive function declined abruptly at younger ages in some participants but remained intact in others until very old age.
In multivariate regression analyses after adjustment for established risk factors, concentrations of holoTC (a marker of reduced vitamin B-12 status), tHcy, and MMA predicted cognitive decline, but folate did not.
A doubling in holoTC concentrations (from 50 to 100 pmol/L) was associated with a 30% slower rate of cognitive decline (�0.137 to �0.083), whereas a doubling in tHcy (from 10 to 20 �mol/L) or MMA (from 0.25 to 0.50 �mol/L) was associated with >50% more rapid cognitive decline (�0.090 to �0.169) and (�0.104 to �0.169), respectively.
After adjustment for all vitamin markers simultaneously, the associations of cognitive decline with holoTC and MMA remained significant.
Conclusions: Low vitamin B-12 status was associated with more rapid cognitive decline. Randomized trials are required to determine the relevance of vitamin B-12 supplementation for prevention of dementia.
Just checked my B-50 supplement and the B12 is cyanocobalamine.
Seems there is a difference between this and methylcobalamin. Why is one better than the other? I'll go check it out myself in a little while but if you have a quick answer, it would be appreciated. TX
The methyl form of cobalamin is "brain ready". It can be utilized directly by the brain and does not require the conversion process that the cyano form does.
In other words, if you use the cyano form ... you're depending on your body's conversion (a process called methylation) in order for it to be altered into a form that your brain can use.
The methylcobalamin form is the direct form. The cyano form requires your body to process it properly (and some bodies may not) in order to benefit your brain in the same way.
Hydroxo seems to be the main injectable B12 given in Australia.
Thanks for the link. I am still trying to get my B12 resolved it is possible I have PA.
I have recently been diagnosed with Coeliac Disease and was diagnosed with Hashimoto's Disease in November 1994
So am not sure whether my ongoing problem with low B12 is from poor absorption because of Celiac or whether I have PA ..... blood test was negative but they only did Parietal Cells and not Intrinsic Factor and blood tests can be very unreliable
Last edited by nutralady2001; 11-18-2007 at 12:41 AM.
Vitamin B-12 and Cognitive Decline
Linear Mode
