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Old 09-02-2008, 12:51 PM
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Default St. John's Wort vs. Prescription Antidepressant

"Forty outpatients who suffered from depression according to the DSM-IV [Diagnostic and Statistical Manual of Mental Disorders, 4th Edition] diagnostic criteria were selected," reported principal investigator Christos Istikoglou, MD, Psychiatric Department, Asklepeion General Hospital of Voula, Athens, Greece, here on September 1, 2008.

Twenty patients received St. John's Wort at a dosage of 900 mg QD, whereas the remaining 20 participants were treated with duloxetine 60  30 mg QD.

In order to evaluate the severity of the depressive symptoms, patient assessments by means of the Hamilton Rating Scale for Depression (HAM-D) and the Montgomery-Asberg Depression Rating Scale (MADRS) were performed on days 1, 15, 30, and 45 as well as after 2 and 3 months.

"In the group of patients suffering from moderate depression, we did not find any statistically significant differences between the 2 treatment groups," Dr. Istikoglou said.

However, in the patients diagnosed with serious depression, treatment with St. John's Wort did not cause any substantial symptomatic improvement. "In this group, duloxetine contributed to a considerable symptom reduction according to the HAM-D and MADRS scales, proving the role that duloxetine plays in the treatment of serious depression," Dr. Istikoglou emphasised (P .01).
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Old 09-15-2008, 07:44 PM
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While they may work for some people, personally I feel that traditional antidepressants are like brute force medicine. The sledge hammer approach. To me it seems that researchers don't know a lot about the brain, but have decided that because they have this one effect of blocking reuptake of serotonin (which is I believe what they do?), that they're happy to hand it out to some crazy percentage of the developed world's population. The brain is so infinitely complex, god only knows what else is being done to it by the antidepressants.
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Old 04-19-2009, 09:51 PM
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Also there is the warnings to consider... "Watch for Suicidal thoughts and behavior"
I don't know about you but I don't think an antidepressant should have suicidal thoughts and behavior as a side-affect.
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