To start off I should say I'm 31 and have started getting serious about taking supplements after doing some research on how to lower my uric acid levels because of gout. I got gout because I went on a low carb diet in my early to mid 20s without doing the proper research. Instead of eating salads with high protein, low fat meats like chicken, I just ate tons of steak, bacon, and brats.

You live and your learn, but after having foot problems a few times I went to a doctor and diagnosed me with gout. I was tempted to take prescription medications for it, but I don't trust the stuff fully, and only use it as a last resort.

Recently I've been getting serious, and not just taking cherry juice, and other supplements for gout, not to mention changing my diet drastically I've also started taking others.

Anyway, I just want to review my regiment, and see what others have to say, give me suggestions on what to take, what not to take, and when to take it.

I take a daily multivitamin from Soloray, 3000 mg of fish oil, CoEnzyme for high blood pressure, Goutrin(a collection of anti-uric acid supplements) Magnesium, and vitamin B2 for headaches, and 7-Keto for weight loss. I also drink Tart cherry for the gout, and Apple Cider Vinegar for weight loss and for the gout.

I've been taking them like this. I drink the Apple Cider Vinegar when I wake up, have my breakfast and take the 7 Keto, I wait a bit then I drink some coffee and let it out of my system for awhile I take the vitamins and fish oil after lunch, I wait a couple hours and take the CoEnzymes, Magnesium, and B2, then I get home take more fish oil, goutrin, and finish my night with a glass of tart cherry juice.
Am I taking anything unnecessarily, am I taking to many supplements in general, do some of them fight against each other, should I be taking them in a different order? Any suggestions/comments are appreciated. Thank you.

High intake of fructose-rich industrialized food and high alcohol intake (particularly beer) seem to be involved in high plasma uric acid.

Vitamin C intake in men is inversely associated with serum uric acid concentrations.

So Vitamin C is probably the first supplement to try. Unfortunately the half life of vitamin C is measured in minutes so although you need a lot of vitamin c and quickly, if you take it all at one it will be down the loo at the next visit.
The way round the problem is to use SMALLER amounts THROUGHOUT the day or if you can find them at a reasonable price slow release/timed release/sustained release vitamin c tablets.

The slow way is to take

"Vitamin C at 500 mg/day for 2 months to reduce serum uric acid concentration "

and the faster way is here "Ascorbic acid-induced uricosuria. A consequency of megavitamin therapy".

4 grams of vitamin C (but not lower amounts) had an increase in urinary excretion of uric acid within a few hours, and those who took 8 grams of vitamin C per day for several days had a reduction in serum uric acid levels.
Vitamin C is incredibly safe.

The vitamin c foundation

I think you'll want to stop the pain ASP so if you're well organised go for 1g capsule every 2 hrs throughout the day and before bed . or if less well organised 2 before each meal and 2 before bed. so either way your total 8 daily I'd do this until symptoms stopped/reduced (a week) then drop the dose down to what you are happy with.

Some people find that vitamin c works as a laxative and obviously if it's going DIRECTLY down the loo it's money wasted and not very pleasant. So at the first sign of bowel intolerance (the runs) you may have to reduce consumption and then restart at one a day then 2 daily at 12hrs intervals than 3 daily at 8hr gaps. and so on until you get to the 8 daily.

The other supplement that may help is Quercetin.
You can buy Quercetin plus Vitamin C mix Capsules
There is not so much or as good evidence for quercetin but it's one of the flavanoids that are in cherries and cherry juice and cherries are supposed to be good for gout. Drinking cherry juice or eating dark cherries daily MAY help prevent it recurring.

I presume I don't have to tell you to cut out FRUCTOSE HFCS or anything that sounds like it comes from corn is probably going to add to the effect
See Corn derivatives here
Corn free

Stress is also a huge trigger for gout attacks, so try some relaxation excercises, stretches, etc...

Stress =cortisol=more inflammation and most people lack sufficient natural anti inflammatory reserves. Vitamin D3 exerts it maximum anti inflammatory action at 125nmol/l 50ng/ml get 25(OH)D TESTED (CityAssays UK �25) and take sufficient vitamin D3 to stay above 125nmol/l (1000iu/daily for each 25lbs you weigh as a starting amount)
Omega 3 resolves inflammation if you also reduce omega 6 corn/soy/sunflower/safflower, cottonseed oil intakes and eliminate grains from your diet 1~2 g omega 3 fish oil will help redress the balance.
Magnesium 400mg daily 100mg with each meal and before bed
Melatonin is also anti~inflammatory time release taken before bed not only improves sleep by helps the body deal with inflammation.

What kind of magneisum do you take? Will just any cheap magnesium pill (from walmart) do?

Magnesium citrate powder is probably the cheapest option but SPREAD the dose through the day and build it up slowly so that your digestive system gets used to it.
Magnesium malate may be an alternative.

Ten important things to know about magnesium

I think Albion Mineral Patent chelates are probably worth paying for.
I also think it's worth trying transdermal treatments. Magnesium Sulphate and magnesium chloride in your bathwater do make it very relaxing and help a good nights sleep.
There are many other magnesium threads on this site and so it's worth searching for them.
i think it's probably as important as Vitamin D so EVERYONE should be ensuring their diet provides AT LEAST the RDA for magnesium and use supplements to ensure that every day you get more than the RDA.

Nettle leaf is one of the best herbs for reducing uric acid. It also helps the thyroid and hypothyroid contributes to elevated uric acid. Unfortunately you will have to stay away from all alcohol. Beer is the worst. High protein and high doses of vitamin C contribute to elevated uric acid as well.

Plenty of water during the day will help.

Tart cherries do help with gout. They are high in malic acid which is the acid that does the trick. So your best magnesium is magnesium malate. Malic acid will actually dissolve uric acid. Uric acid does not cause gout though. The cause can be things like alcohol, hypothyroidism, and medications, and high purine intake in your diet https://whfoods.org/genpage.php?tname=george&dbid=51 That is why beer should be avoided. High purines. Seaweeds can aggravate gout too. Foods with yeast don't help either.

__________________
.
- Jim

Love is a serious mental disease. -Plato

The effects of vitamin C supplementation on serum concentrations of uric acid: Results of a randomized controlled trial full text at link

Seaweed is an Extremely Alkaline Forming Food
Uric acid elimination increases as the urine reaches an alkaline pH state
Uric Acid elimination is reduced as it becomes acidic.
Urine at pH 7.0 is neutral
Elimination of uric acid decreases by approximately 50% at pH 6.5.

Black Cherry Juice Concentrate
Gout: Black Cherries half pound a day or equilivant amt of juice
To lower uric reduce purines in diet abstain from red meat, organ meats, beans, pea, spinach and yeast, alcohol
Take Vitamin C to bowel tolerance and folic acid of 40 to 80 mg per day


or:

Pantothenic Acid (vit B5) 500mg 3x day
This will neutralize the uric acid while in the blood. If you do this you will have to add at least 400mg of magnesium citrate and B6 100mg. You must do this also to keep things in balance

You can use very high doses of pantothenic acid. Start with 500mg 3 xd.
Then increase to 1000mg 3xday and after 5 days retest the uric acid blood level. But if they have gout or gouty arthritis where they just feel generally achy you will know that the uric acid levels are coming down because they will feel better. But you have to take the magnesium and B6 also.

On rare occasions you might have to go up to 2500mg 3xday then retest after 5 days. Pantothenic acid is not toxic and you can not overdose. On other rare occasions 3,00mg 3 xday may be needed. You will know how much to take by how you feel after 5 days.

__________________

I would not consider that 500 mg per day is a high dose. I would consider more than 2g per day though. And such high dose can contribute to higher levels of uric acid.

As is seen in one of your previous links. https://www.ncbi.nlm.nih.gov/pubmed/1259282

I would have thought the opposite. If you've got high levels of uric acid and you lose that through your urine I would have thought that would reduce the problem.
Gout and Hyperuricemia
I appreciate that the high vit c dose could precipitate kidney stones but I can't see why getting rid of uric acid could increase guot.

I haven't done so much research on this and only a little experience. I only know that nettle leaf works well to help eliminate uric acid. It also lowers lactic acid. I'm pretty acquainted with herbs you see. Nettle is one of the herbs that is even high in vitamin C. I recommend the powder. 1/2 teaspoon about twice a day. The tea would help longer term.

Now, thinking on what you said about lowering uric acid might increase gout, I'm not sure about that. I believe that high dose vitamin C elevates uric acid, but may not necessarily lead to increasing gout. That is only one thing that will elevate uric acid. It is a product of the inability of the body to process the purines in the food that we eat, or medicines, or hypothyroid, etc. Gout is due to an overload of uric acid forming tiny crystals which get deposited in body tissues and joints. So anything that can dissolve those crystals will alleviate the gout conditions, but may not necessarily decrease uric acid. Malic acid will dissolve them. Juniper berries can too, but I don't recommend them due to there ability to drastically lower blood sugar.

According to your links, some vitamin C is good as well, but I don't know if it stops the formation of those urate crstals. If uric acid is being eliminated in the urine with 500mg of ascorbic acid, it may be that the ascorbic acid is acting as a diuretic. It does for me. It is known that it is very helpful to drink a lot of water to hydrolize the uric acid, as well as flush it and other toxins from the body. When uric acids are raised, the kidneys are unable to eliminate it effectively. But it can also mean that the kidneys are not functioning properly in the first place for the uric acid levels to be increasing. The study just did not say what is really happening. At least not satisfactorily enough for me.

I'm not in any way saying that you are incorrect. Increased levels of uric acid are caused by so many conditions. It is as bad as trying to determine the reason for high blood pressure. Heck, even high blood pressure is linked to high uric acid levels. That's something I know from research and personal experience. Gout is a symptom, but high uric acid is a symptom too.

Large supplemental doses of vitamin C can also increase levels of uric acid in the urine, because vitamin C can be broken down into uric acid. Again, I indicate "Large", but don't know what that really means. Oxalic acid can also be synthesized by ascorbic acid. Both oxalic and uric acids can cause kidney stones.

BTW, seaweeds are high in purines. That's why they aggravate gout.

Controldenied needs to look for the cause of the uric acid levels. Could even be as bad as cancer, or as simple as high fructose corn syrup or caffeine. It may be more than just a diet high in protein.

Magnesium malate is magnesium bound with malic acid. Apples contain malic acid too.

Thanks for the above education.
This may actually be a lot more serious than just GOUT (not that Gout is a laughing matter) but Friend or Foe? Uric Acid a 'Probable Cause' of CVD

Ascorbic acid does not contribute to kidney stones, that is a myth.

Ascorbic acid does not contribute to gout, that is also a myth.

The above pubmed study is from over 35 years ago, and can't be trusted.

Uric acid is not manufactured by the body, that is also a myth. Uric acid is excreeted by fungi, so if you have gout you also have a fungal issue... and what feeds fungus? Sugar, alcohol, bakers yeast, brewers yeast, and simple carbs in any form.

Ascorbic acid is antifungal, thus, getting rid of the fungus also gets rid of the gout.

There are numerous more modern studies of gout and uric acid on Pubmed. Some even genetic. https://www.ncbi.nlm.nih.gov/pubmed?t...%20acid%20gout

I haven't found any yet associating it with fungus. Although, there are many reasons for the formation of uric acid.

And vitamin C can indeed cause formation of oxalates which can then cause formation of kidney stones. Here is one modern study that indicates that it is better to use ester-C to avoid the oxalate formation.