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Old 02-06-2013, 03:45 PM
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Default Obesity and vitamin D - surprise findings

Study finds that obesity can lead to lack of vitamin D


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Old 03-30-2013, 06:34 PM
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maybe it's my imagination, but it seems like vitamin d is getting over hyped lately. I wouldn't be surprised if claims that it cures cancer, hiv or anything else in between. could it possible be that those that are obese are less likely to get any Sun and less likely to consume foods that contain vitamin d?
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Old 03-30-2013, 11:47 PM
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Steroid hormones such as cortisone, estrogen, and testosterone have four carbon rings. Ultraviolet B radiation in sunlight breaks open one of the rings in a steroid alcohol present in the skin, 7-dehydrocholesterol, to form vitamin D (cholecalciferol). The liver changes this molecule into its circulating form, 25-hydroxyvitamin D (calcidiol, 25[OH]D), the "vitamin D" blood tests measure. Cells throughout the body absorb 25-hydroxyvitamin D and change it into 1,25-dihydroxyvitamin D (calcitriol), the active form of vitamin D that attaches directly to receptors on the DNA of genes in the cell�s nucleus.
The vitamin D hormone system controls the expression of more than 200 genes and the proteins they produce. In addition to its well-known role in calcium metabolism, vitamin D activates genes that control cell growth and programmed cell death (apoptosis), express mediators that regulate the immune system, and release neurotransmitters (e.g., serotonin) that influence one�s mental state.

Some of the genes vitamin D activates make proteins that halt cancer by inducing apoptosis (programmed cell death), which destroys aberrant cells before they become cancerous, like adenoma cells in the colon and rectum. Others promote cell differentiation and reining in of out-of-control growth of cancer cells (like prostate cancer cells). Vitamin D-expressed genes inhibit angiogenesis, the formation of new blood vessels that malignant tumors need to grow, as studies on lung and breast cancers show. Other genes inhibit metastases, preventing cancer that arises in one organ from spreading its cells to other parts of the body, as studied in breast, and prostate cancers.

Multiple sclerosis (MS) is a neurologically devastating disease that afflicts people with low vitamin D levels. Its victims include the cellist Jacqueline Du Pr�, whose first symptom was loss of sensation in her fingers, and some 500,000 Americans who currently suffer from this malady. MS is an autoimmune disease, where the body�s immune system attacks and destroys its own cells. With multiple sclerosis, T cells in the adaptive immune system, Th1 cells (CD4 T helper type 1 cells), attack the myelin sheath (insulation) of the axons (nerve fibers) that neurons (brain cells) use to transmit electrical signals. The Vitamin D hormone system regulates and tones down the potentially self-destructive actions of Th1 cells. These cells make their own 1,25-dihydroxyvitamin D if there is a sufficient amount of vitamin D (25-hydroxyvitamin D) circulating in the blood. Researchers have shown that the risk of MS decreases as the level of vitamin D in the blood increases (JAMA 2006;296:2832�2838). People living at higher latitudes have an increased risk of MS and other autoimmune diseases. Studies show that people who live below latitude 35� (e.g., Atlanta) until the age of 10 reduce the risk of MS by 50% (Toxicology 2002;181�182:71�78 and Eur J Clin Nutr 2004;58:1095�1109).
In a study published earlier this year, researchers evaluated 79 pairs of identical twins where only one twin in each pair had MS, despite having the same genetic susceptibility. They found that the MS-free twin had spent more time outdoors in the sun � during hot days, sun tanning, and at the beach. The authors conclude that sunshine is protective against MS (Neurology 2007;69:381�388).

The majority of the world�s population now lives above latitude 35� N and is unable to synthesize vitamin D from sunlight for a period of time in winter owing to the angle of the sun. At a large solar zenith angle, ozone in the upper atmosphere will completely block UVB radiation. In Seattle (47� N) and London (52� N), from October to April UVB photons are blocked by the atmosphere so one�s skin cannot make vitamin D. (The half-life of circulating vitamin D is approximately one month.) Making matters worse, even when UVB radiation is available in sunlight, health authorities, led by the American Academy of Dermatology, warn people to shield themselves from the sun to avoid getting skin cancer.

I'd rather meander for the prevention than race for the cure.
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Old 03-31-2013, 01:04 AM
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Originally Posted by knightofalbion View Post
Study finds that obesity can lead to lack of vitamin D

Anyone who thinks 50nmol/l us a "healthy" 25(OH)D level hasn't been paying attention to the recent research.

The NATURAL level for humans living as human DNA evolved (near naked outdoor lives in East Africa) is around 125nmol/l or 50ng/ml at which level human milk is a vitamin d replete food for human babies. At 50ng/ml 125nmol/l the Vitamin exerts it's most potent anti inflammatory action.

When people are obese the fat cells produce pro-inflammatory cytokines and the body uses up Vitamin D resolving that inflammation hence 25(OH)D are always lower in obese/overweight people.
It makes sense to relate Vitamin D intake to body weight so bigger bodies get more vitamin d, One size doesn't fit all with vitamin d.

Whatever daily intake you suggest there will be a 100ng/ml or 250nmol/l range in the response, from the fattest to the thinnest person taking that daily amount.

So the only sensible suggestion is to a get 25(OH)D tested regularly (every 3~6 months) until such time as it takes you to work out how much vitamin d your body requires to stay around the level 50~60ng/ml 125~150nmol/l we know is natural for human DNA.

If you ran your car with oii/water/air/or brake fluid levels/pressures 25% ~50% of the makers orignal specifications you would spend more time dealing with problems at the garage. Keeping the population with Vitamin D levels less than half that human DNA evolved to attain and maintain provides a lot of extra work for health professionals and those who depend on the health industry for their profits. Hence the reluctance to see the obvious connection between low vitamin d status and health problems.

City Assays Vitamin D Blood Spot Test �25 UK �30 overseas

Grassrootshealth also do Vitamin D blood spot testing there is a Vitamin D measurement converter on their website.
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