https://www.neilmed.com/pdf/babyshampoo.pdf
Here is an excerpt of that PDF. Notice "One percent baby shampoo in normal saline was the optimal concentration for inhibition of Pseudomonas biofilm formation."
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Baby shampoo nasal irrigations for the symptomatic
post�functional endoscopic sinus surgery patient
Alexander G. Chiu, M.D., James N. Palmer, M.D., Bradford A. Woodworth, M.D., Laurel Doghramji, R.N., Michael B. Cohen, B.A., Anthony Prince, B.A., and Noam A. Cohen, M.D., Ph.D.
ABSTRACT
Background: Symptoms of postnasal drainage and thickened mucus are commonly seen in patients with chronic rhinosinusitis (CRS) recalcitrant to sinus surgery and conventional medical therapies. Chemical surfactants can act as a mucolytic by reducing water surface tension and have the potential to serve as an antimicrobial agent. Baby shampoo is an inexpensive, commercially available solution containing multiple chemical surfactants. This is an in vitro study of its antimicrobial effects on Pseudomonas biofilms with translation to a clinical study for use as an adjuvant nasal wash in patients with CRS who remain symptomatic despite adequate sinus surgery and conventional medical therapies.
Methods: In vitro testing was performed to determine the optimal concentration of baby shampoo that disrupted preformed bacterial biofilms and inhibited biofilm formation. This concentration was then used in a prospective study of symptomatic post�functional endoscopic sinus surgery (FESS) patients who irrigated twice a day for 4 weeks. Validated outcome forms and objective smell testing was performed before and after therapy.
Results: One percent baby shampoo in normal saline was the optimal concentration for inhibition of Pseudomonas biofilm formation. Baby shampoo had no effect on the eradication of preformed Pseudomonas biofilms. Eighteen patients with CRS with an average of 2.8 surgeries were studied after irrigating with 1% baby shampoo solution. Two patients discontinued use because of minor nasal and skin
irritations; 46.6% of patients experienced an overall improvement in their subjective symptoms, and 60% of patients noted improvement in specific symptoms of thickened mucus and postnasal drainage.
Conclusion: Baby shampoo nasal irrigation has promise as an inexpensive, tolerable adjuvant to conventional medical therapies for symptomatic patients after FESS. Its greatest benefit may be in improving symptoms of thickened nasal discharge and postnasal drainage.
(Am J Rhinol 22, 34�37, 2008; doi: 10.2500/ajr.2008.22.3122)
Apparently adding a drop of baby shampoo to saline spray will disrupt the biofilm which protects the fungi/molds/bacteria. Biofilm created by these organisms is the primary cause for (pharmal or natural) anti-fungal or anti-biotic resistant infections.
Baby shampoo cantains a zwitterionic surfactant, which disrupts this. See study below and/or google .
https://www.ncbi.nlm.nih.gov/pubmed/17883887
Methods for removing bacterial biofilms: in vitro study using clinical chronic rhinosinusitis specimens.
Desrosiers M, Myntti M, James G.
Abstract
BACKGROUND: Bacterial biofilms may be involved in refractory chronic rhinosinusitis (CRS). In vitro, we studied methods for removing biofilms formed by Staphylococcus aureus and Pseudomonas aeruginosa.
METHODS: Bacterial isolates were obtained from patients with refractory CRS and were plated and treated with either static administration of citric acid/zwitterionic surfactant (CAZS), saline delivered with hydrodynamic force, or CAZS delivered hydrodynamically. Results were assessed by counting colony-forming units (CFUs) and by confocal scanning laser microscopy (CSLM).
RESULTS: All treatments produced significant reductions in CFU counts (p >or= 0.002). Hydrodynamic CAZS provided the greatest reduction, decreasing CFU counts from control values by 3.9 +/- 0.3 logs and 5.2 +/- 0.5 logs for S. aureus and P. aeruginosa, respectively (99.9% reduction; p = 0.001). CSLM showed decreases in biofilm coverage.
CONCLUSION: Hydrodynamic delivery of a soap-like surfactant and a calcium-ion sequestering agent may disrupt biofilms associated with CRS. Our results may be relevant to a new approach to refractory CRS.
Baby shampoo for nasal irrigation
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