Go Back Natural Medicine Talk > Health > Systems & Organs

LinkBack Thread Tools Display Modes
� #1
Old 02-21-2008, 09:54 AM
Harry Hirsute's Avatar
Join Date: Apr 2006
Location: Propecia, CA
Posts: 1,849
Harry Hirsute will become famous soon enough
Default Picrorhiza Kurroa May Help to Heal Ulcers

Picrorhiza Kurroa is often used as a liver tonic but this is another potential application worth considering ...


The present study was undertaken to evaluate the potential of the rhizomes of the Indian medicinal plant, Picrorhiza kurroa in healing indomethacin-induced acute stomach ulceration in mice and examine its capacity to modulate oxidative stress and the levels of prostaglandin (PGE2) and EGF during the process.


Male swiss albino mice, ulcerated with indomethacin (18 mg/kg, p. o., single dose) were treated up to 7 days with different doses of the methanol extract of P. kurroa rhizomes (designated as PK). The healing capacity of the most effective dose of PK (20 mg/kg, p. o. x 3 d) was compared with that of omeprazole (Omez) (3 mg/kg, p. o. x 3 d).

The effects of the drug-treatment for one and three days on the biochemical parameters were assessed by comparing the results with that of untreated mice of the 1st and 3rd day of ulceration. The stomach tissues of the mice were used for the biochemical analysis.


The macroscopic indices revealed maximum ulceration on the 3rd day after indomethacin administration, which was effectively healed by PK. Under the optimized treatment regime, PK and Omez reduced the ulcer indices by 45.1% (P<0.01), and 76.3% respectively (P<0.001),compared to the untreated ulcerated mice.

Compared to the ulcerated untreated mice, those treated with PK for 3 days showed decreased the levels of thiobarbituric acid reactive substances (TBARS) (32.7%, P< 0.05) and protein carbonyl (37.7%, P<0.001), and increased mucin (42.2%, P<0.01), mucosal PGE2 (21.4%, P<0.05), and expressions of COX-1 and 2 (26.9% and 18.5%, P<0.05), EGF (149.0%, P<0.001) and VEGF (56.9%, P<0.01). Omez reduced the TBARS (29.4%, P<0.05), and protein carbonyl (38.9%, P<0.001), and increased mucin (38.3%, P<0.01), without altering the other parameters significantly.


PK (20 mg/kg, p. o. x 3 days) could effectively heal indomethacin-induced stomach ulceration in mice by reducing oxidative stress, and promoting mucin secretion, prostaglandin synthesis and augmenting expressions of cyclooxygenase enzymes and growth factors .
You're officially invited to visit my natural health blog: www.healthyfellow.com
Reply With Quote
Reply Bookmark and Share

Thread Tools
Display Modes

Similar Threads
Thread Thread Starter Forum Replies Last Post
Before & After Photos - MMS & Venous Stasis Ulcers Lynnwood Alternative Therapies 0 08-15-2010 03:44 PM
Alternative Answers for Peptic Ulcers kind2creatures Systems & Organs 5 02-26-2010 02:35 PM
eye ulcers in my doggie :( scorpiotiger Pet Health 22 12-22-2008 10:57 PM
Avocados May Help Wounds Heal Harry Hirsute Nutrition 4 05-14-2008 09:19 PM
Pine Oil for Ulcers Iggy Dalrymple Systems & Organs 2 11-10-2007 04:56 AM