12-11-2007, 05:17 PM
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Lecturer
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Join Date: Apr 2006
Location: Propecia, CA
Posts: 1,852
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High Fiber Intake May Lessen Atherosclerosis Risk
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Dietary fiber intake and retinal vascular caliber in the Atherosclerosis Risk in Communities Study.
Kan H, Stevens J, Heiss G, Klein R, Rose KM, London SJ.
Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC and the Department of Epidemiology, School of Public Health, the University of North Carolina at Chapel Hill, NC).
BACKGROUND: Dietary fiber appears to decrease the risk of cardiovascular morbidity and mortality. Microvascular abnormalities can be observed by retinal examination and contribute to the pathogenesis of various cardiovascular diseases. The impact of dietary fiber on the retinal microvasculature is not known.
OBJECTIVE: We aimed to examine the association between dietary fiber intake and retinal vascular caliber.
DESIGN: At the third visit (1993-1995) of the Atherosclerosis Risk in Communities (ARIC) Study, a population-based cohort of adults in 4 US communities, the retinal vascular caliber of 10 659 participants was measured and summarized from digital retinal photographs. Usual dietary intake during the same period was assessed with a 66-item food-frequency questionnaire.
RESULTS: After control for potential confounders including hypertension, diabetes, lipids, demographic factors, cigarette smoking, total energy intake, micronutrients intake, and other cardiovascular disease risk factors, higher intake of fiber from all sources and from cereal were significantly associated with wider retinal arteriolar caliber and narrower venular caliber.
Participants in the highest quintile of fiber intake from all sources had a 1.05-mum larger arteriolar caliber (P for trend = 0.012) and a 1.11-mum smaller venular caliber (P for trend = 0.029).
CONCLUSIONS: Dietary fiber was related to wider retinal arteriolar caliber and narrower venular caliber, which are associated with a lower risk of cardiovascular disease. These data add to the growing evidence of the benefits of fiber intake on various aspects of cardiovascular pathogenesis.
PMID: 18065579 [PubMed - as supplied by publisher]
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https://www.ncbi.nlm.nih.gov/sites/en..._uids=18065579
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10-10-2008, 11:17 AM
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Lecturer
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Join Date: Apr 2006
Location: Propecia, CA
Posts: 1,852
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Quote:
Am J Clin Nutr. 2008 Oct;88(4):1119-25.
Dietary fiber intake in relation to coronary heart disease and all-cause mortality over 40 y: the Zutphen Study.
Streppel MT, Ock� MC, Boshuizen HC, Kok FJ, Kromhout D.
National Institute for Public Health and the Environment, and the Division of Human Nutrition, Wageningen University, Wageningen, Netherlands.
BACKGROUND: Little is known about the effects of dietary fiber intake on long-term mortality. OBJECTIVE: We aimed to study recent and long-term dietary fiber intake in relation to coronary heart disease and all-cause mortality.
DESIGN: The effects of recent and long-term dietary fiber intakes on mortality were investigated in the Zutphen Study, a cohort of 1,373 men born between 1900 and 1920 and examined repeatedly between 1960 and 2000. During that period, 1,130 men died, 348 as a result of coronary heart disease. Hazard ratios were obtained from time-dependent Cox regression models.
RESULTS: Every additional 10 g of recent dietary fiber intake per day reduced coronary heart disease mortality by 17% (95% CI: 2%, 30%) and all-cause mortality by 9% (0%, 18%). The strength of the association between long-term dietary fiber intake and all-cause mortality decreased from age 50 y (hazard ratio: 0.71; 95% CI: 0.55, 0.93) until age 80 y (0.99; 0.87, 1.12). We observed no clear associations for different types of dietary fiber.
CONCLUSIONS: A higher recent dietary fiber intake was associated with a lower risk of both coronary heart disease and all-cause mortality. For long-term intake, the strength of the association between dietary fiber and all-cause mortality decreased with increasing age.
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https://www.ncbi.nlm.nih.gov/pubmed/1...?dopt=Abstract
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