Here is the full text of the paper the above article was based upon.
The Curry Spice Curcumin Reduces Oxidative Damage and Amyloid Pathology in an Alzheimer Transgenic Mouse Bear in mind that was nearly 10 years ago and much has happened since then to confirm the benefits of curcumin.
The full text of this article is available online,
Why Pleiotropic Interventions are Needed for Alzheimer's Disease and it has a long section on the different ways curcumin may be working to prevent Alzheimer's. They also spend time discussing the benefits of the omega 3 component DHA from fish oil. What both DHA and curcumin have in common is that they BOTH can activate the Vitamin D receptor and both work in synergy with Cholecalciferol (vitamin D3). However I wouldn't want anyone to JUST use curcumin or just use vitamin D3 or just use DHA. They know that different gene groups work better with one than the other so as it's almost impossible or would be very expensive to get your genes tested to find out if your potential for Alzheimer's was best reduced by one or other of the threesome it's cheaper and safer to make sure you have adequate amounts of each available.
As far as the omega 3 DHA is concerned readers have to be aware that current levels of omega 6 from industrial seed oils particularly soya, but also corn, sunflower, safflower cottonseed etc are so high that they displace omega 3 from it's position in the cells. So whatever intake of omega 3 you will will be futile if it cannot get into and maintain is position in your cells. So fundamental to considering your omega 3 status is the elimination of soyabean, corn and sunflower and the like industrial seed oils and all the foods that contain them. You also have to understand that most US adults have about 30 times too much omega 6 and far too little omega 3. The half life of omega 6 in the body is roughly 2 yrs so stopping all unnecessary additional omega 6 intake while increasing omega 3 (ideally around 2g of EPA + DHA daily) will see a measurable difference in plasma levels within a fortnight but it will be 2yrs before that makes a noticeable difference to cell levels and it could be 5 yrs before you get back to the omega 3 omega 6 ration around 1<> 1 or at least around 1 omega 3 <> to below 5 omega 6. Around that level the omega 3 can hold it's own but above that level more omega 6 = less omega 3.
There is a bit of a bioavailability issue with curcumin and it's thought that much of the plain dietary form is not absorbed, although clearly it's probable that the daily use of curcumin by asians who continue to eat traditionally when living at high latitude than originally does seem to protect them to some extent from the vitamin D deficiency common at higher latitudes. But people who are unlikely they will be consuming turmeric spiced foods all day every day may appreciate knowing.
Life Extension, Super BIO-Curcumin
Doctor's Best, Meriva, Phytosome Curcumins
Are forms that have been devised to make the uptake more effective.
As for DHA I use a liquid fish oil such as
Nature's Answer, Liquid Omega-3, Deep Sea Fish Oil EPA/DHA because each teaspoon provides EPA (Eicosapentaenoic Acid) 800 mg DHA (Docosahexaenoic Acid) 500 mg = 1300mg so just under 2 teaspoons gets me over the 2g daily amounts. and being a liquid fish oil I can taste if it's beginning to go off and tastes rancid.
I find keeping the bottle in the fridge and only taking it out of the fridge while I am using it and putting it straight back before it reaches room temperature seems to work fine for me.
There are high strength alternative capsules
Now Foods, Ultra Omega-3, 500 EPA/250 DHA
Omega-3 Fatty Acids 750 mg Eicosapentaenoic Acid (EPA) 500 mg
Docosahexaenoic Acid (DHA) 250 mg that mean you can manage with 4 capsules daily
Similarly with Vitamin D3 taking less than 5000iu/daily like
Country Life, Vitamin D3, 5,000 IU, is unlikely to raise 25(OH)D levels into the range at which D3 is stored in cells.
Ideally you need to be around 60ng/ml and that probably requires around 1000iu/daily for each 25lbs you weigh but regular 25(OH)D testing will show how much daily your body requires to keep at a natural vitamin D status.
Because these are supplements that the body requires daily to maintain adequate status we have to understand this means a lifetime commitment or investment in health which is why it's important to look for the cheapest source, including shipping charge to your location. Which is why I use IHERB and suggest to people they also share their IHERB rewards codes like mine WAB666 so new users to IHERB enjoy a $5 discount why the regular users benefit for extra bonus discounts. Helping others by making the regular use of effective strength and forms of supplements affordable should be encouraged wherever possible. UK readers have also to take into account the fact customs adds VAT to orders over �18 value and our PO adds a �8 handling charge. So if your order comes to more than �18 before shipping charge added you may do better to use DHL shipping as their handling fee for collecting the tax is just �1.25.
US readers should shop around as your total cost will vary depending on the delivery charge and other online discount providers will vary.