Bicarbonate increases tumor pH and inhibits spontaneous metastases. Robey IF, Baggett BK, Kirkpatrick ND, Roe DJ, Dosescu J, Sloane BF, Hashim AI, Morse DL, Raghunand N, Gatenby RA, Gillies RJ.
Arizona Cancer Center, University of Arizona, Tucson, Arizona, USA. Abstract
The external pH of solid tumors is acidic as a consequence of increased metabolism of glucose and poor perfusion. Acid pH has been shown to stimulate tumor cell invasion and metastasis in
It appears that a long duration of taking sodium bicarbonate could cause problems. At least, in rats. I figure that it is not good to keep the stomach acids low.
But notice that they do not say whether they added the bicarbonate to the food. That would be very bad over the duration. The stomach acids would be neutralized. Must have common sense. Cautionary guidance would be that you should not take sodium bicarbonate with food. It would not...
Preventive effects of bicarbonate on cerivastatin-induced apoptosis. Kobayashi M, Kaido F, Kagawa T, Itagaki S, Hirano T, Iseki K.
Department of Clinical Pharmaceutics & Therapeutics, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-12-jo, Nishi-6-chome, Kita-ku, Sapporo 060-0812, Japan. Abstract
Although HMG-CoA reductase inhibitors such as statins are the most widely used cholesterol-lowering agents, there is a risk of myopathy...
This article indicates that you should not try to manipulate your body into an alkaline or acid environment. At least, not for the longer duration. The duration, of this study, was 1 year. I suppose that you won't go that long with the sodium bicarbonate cancer protocol.
But notice that they added the sodium bicarbonate to the food or diet. This would neutralize and important part of the digestive system - stomach acid.
Once again, we are reminded that "The extracellular (interstitial) pH (pHe) of solid tumours is significantly more acidic compared to normal tissues."
This article indicates that chemotherapy can be enhanced by drinking water with sodium bicarbonate added. The article is about breast cancer, but it seems that the same would be true for other forms. It would depend upon whether the drug is a weak base (alkaline). You would be improving that alkalinity with the use of...
Osmotic shock or osmotic stress is a sudden change in the solute concentration around a cell, causing a rapid change in the movement of water across its cell membrane. Under conditions of high concentrations of either salts, substrates or any solute in the supernatant, water is drawn out of the cells through osmosis. This also inhibits the transport of substrates and cofactors into the cell thus �shocking� the cell. Alternatively, at low concentrations of solutes, water enters the cell in large...
This is from a news release from UC San Diego. I'll provide a link to the PNAS.org article below.
Researchers at the University of California, San Diego (UCSD) School of Medicine have determined that a particular type of cellular stress called osmotic stress is of critical importance to cell growth and the body�s immune response against infection. The findings may have implications for autoimmune disorders, transplant rejections, and potential cancer therapies.
Clinical effects of cesium intake. Melnikov P, Zanoni LZ.
Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil. Abstract
The knowledge about cesium metabolism and toxicity is sparse. Oral intake of cesium chloride has been widely promoted on the basis of the hypothesis referred to as "high pH cancer therapy", a complimentary alternative medicine method for cancer treatment. However,...
By now, I'm overwhelmed with all the articles, I've read, with "doctor-speak". It is almost as incomprehensible as Alan Greenspan's Fed-speak. It makes it difficult for someone like me to provide search criteria. I'm pleased with what I've found, and now have to really try to interpret it. These next gleanings came fromhttps://www.jleukbio.org/cgi/content/full/69/4/522
I really encourage you to read it for yourself. I tried not to take anything out of context, but it was hard,...
The role of intracellular pH (pHi) regulation in hematopoiesis is an area of research that has received little attention. Yet the concern for maintaining pH as an important parameter in all in vitro work is well known. By keeping the extracellular pH (pHe) constant, we assume that the cells will be able to regulate their own pHi. This is indeed the case because cells are equipped with several different exchangers to help regulate pHi and to counteract acidification either by efflux of H+ ions or...
