\r\n\r\n\r\n \r\n\r\n\r\n \r\n \r\n\r\n
Go Back � Natural Medicine Talk > Health > Diabetes
Reload this Page IRON diabetes, obesity melatonin
Register Blogs Wiki FAQ Social Groups Search Today's Posts Mark Forums Read

�
�
LinkBack Thread Tools Display Modes
\r\n <!-' + '- user info -' + '->\r\n \r\n \r\n \r\n \r\n \r\n \r\n \r\n
Ted_Hutchinson\'s Avatar\r\n\r\n
\r\n \r\n Ted_Hutchinson\r\n Ted_Hutchinson is offline\r\n\r\n\r\n \r\n \r\n
\r\n\r\n
Lecturer
\r\n \r\n \r\n 		�\r\n\r\n
\r\n
Join Date: May 2009
\r\n \r\n \r\n
\r\n Posts: 1,783\r\n
\r\n
Blog Entries: 4
\r\n \r\n
Ted_Hutchinson will become famous soon enoughTed_Hutchinson will become famous soon enough
\r\n \r\n
\r\n
\r\n\r\n
\r\n <!-' + '- / user info -' + '->\r\n
\r\n \r\n <!-' + '- message, attachments, sig -' + '->\r\n\r\n \r\n\r\n \r\n <!-' + '- icon and title -' + '->\r\n
\r\n \r\n\r\nDefault\r\n\r\n IRON diabetes, obesity melatonin\r\n
\r\n
\r\n <!-' + '- / icon and title -' + '->\r\n \r\n\r\n <!-' + '- message -' + '->\r\n
\r\n \r\n I\'ve previously pointed to the free full text online paper
\r\nThe Role of Impaired Mitochondrial Lipid Oxidation in Obesity that explains the role of dsyfunctional mitochondria in weight regain after dieting.
\r\nand how because melatonin has a vital role in protecting the mitochondria from iron oxidation (it acts as an iron chelator) it\'s got an important role. See
\r\nMelatonin Boosts Weight Loss Goals and Lowers Heart Disease Risk
\r\n
\r\nTo add to this story we see in this abstract how removing iron and the damage it causes helps sort out the problems caused by overweight.
\r\n
\r\nIron reduction by deferoxamine leads to amelioration of adiposity via the regulation of oxidative stress and inflammation in obese and type 2 diabetes KKAy mice.
\r\n
\r\nObviously one quick way of getting rid of excess iron is to donate blood but in the UK there is a limit to the frequency you\'re allowed to donate (every 4 months) So you need other strategies to keep iron low.
\r\n
\r\nIron Behaving badly
\r\nI\'ve removed hundreds of links to references in the quote from this paper because they make it very difficult to read. The full text without the bold text to those most readily available is free full text online.
\r\n
\r\n
Quote:
\r\n \r\n \r\n \r\n \r\n
\r\n \r\n There is also a considerable and positive role for nutrients in terms of their chelation of iron.
\r\n Indeed, polyphenolic compounds, many of which have known health benefits , are widely used as food antioxidants. There is of course considerable epidemiological evidence for the benefits of consuming fruit and vegetables that are likely to contain such antioxidants and � although possibly a minimum � this has been popularised as the \'five a day\' message
\r\n Even though elements of the \'Mediterranean\' diet that are considered to be beneficial are usually assumed to be so on the basis of their antioxidant capabilities many of the polyphenolic compounds (e.g. flavones, isoflavones, stilbenes, flavanones, catechins (flavan-3-ols), chalcones, tannins and anthocyanidins) so implicated may also act to chelate iron as well . This is reasonable given that many of these polyphenols and flavonoid compounds have groups such as the catechol moiety that are part of the known iron-binding elements of microbial siderophores. Examples include flavones such as quercetin, baicalin, curcumin, kolaviron , flavonol floranol xanthones such as mangiferin , morin, catechins and theaflavins as well as procyanidins and melatonin. However, the celebrated (trans-)-resveratrol molecule may act mainly via other pathways.
\r\n
\r\nA considerable number of studies with non-purified dietary constituents containing the above polyphenolic components have also shown promise in inhibiting diseases in which oxidative stress is implicated. For instance in stroke and related neuronal aging and stress conditions, preventative activity can be found in blueberries, Ginkgo biloba extract , grapes , green tea , Mangifera indica extract Strawberries, spinach and Crataegus, while combinations of some these components (\'protandim\') have been claimed to reduce ROS levels by stimulating the production of catalase and SOD. As with pharmaceutical drugs , there are significant problems with bioavailability , although the necessary measurements are starting to come forward. There is now increasing evidence for the mechanisms with which these dietary components and related natural products and derivatives (often with anti-inflammatory, anti-mutagenic or anti-carcinogenic properties) interact with well recognised cellular signalling pathways\r\n \r\n
\r\n
\r\n
\r\n <!-' + '- / message -' + '->\r\n\r\n \r\n\r\n \r\n \r\n\r\n \r\n\r\n \r\n\r\n \r\n\r\n
\r\n <!-' + '- controls -' + '->\r\n \r\n \r\n \r\n Reply With Quote\r\n \r\n \r\n \r\n \r\n \r\n \r\n \r\n \r\n \r\n \r\n <!-' + '- / controls -' + '->\r\n
\r\n\r\n <!-' + '- message, attachments, sig -' + '->\r\n\r\n
\r\n\r\n\r\n<!-' + '- post 186665 popup menu -' + '->\r\n\r\n<!-' + '- / post 186665 popup menu -' + '->\r\n\r\n\r\n\r\n\r\n
\r\n \r\n
\r\n
\r\n
\r\n\r\n<!-' + '- / close content container -' + '->\r\n\r\n<!-' + '- / post #186665 -' + '->'; pd[186667] = '<!-' + '- post #186667 -' + '->\r\n\r\n <!-' + '- open content container -' + '->\r\n\r\n
\r\n
\r\n
\r\n\r\n
\r\n <!-' + '- this is not the last post shown on the page -' + '->\r\n\r\n\r\n\r\n\r\n\r\n \r\n\r\n\r\n \r\n\r\n\r\n \r\n \r\n\r\n
\r\n
\r\n �\r\n #2 �\r\n \r\n \r\n \r\n \r\n \r\n
\r\n\r\n
\r\n <!-' + '- status icon and date -' + '->\r\n Old\r\n \r\n 09-16-2011, 09:25 AM\r\n \r\n \r\n <!-' + '- / status icon and date -' + '->\r\n
\r\n
\r\n <!-' + '- user info -' + '->\r\n \r\n \r\n \r\n \r\n \r\n \r\n \r\n
\r\n\r\n
\r\n \r\n jfh\r\n jfh is offline\r\n\r\n\r\n \r\n \r\n
\r\n\r\n
Moderator
\r\n \r\n \r\n 		�\r\n\r\n
\r\n
Join Date: Dec 2007
\r\n
Location: Texas, USA
\r\n \r\n
\r\n Posts: 3,875\r\n
\r\n
Blog Entries: 16
\r\n \r\n
jfh will become famous soon enoughjfh will become famous soon enough
\r\n \r\n
\r\n
\r\n\r\n
\r\n <!-' + '- / user info -' + '->\r\n
\r\n \r\n <!-' + '- message, attachments, sig -' + '->\r\n\r\n \r\n\r\n \r\n <!-' + '- icon and title -' + '->\r\n
\r\n \r\n\r\nDefault\r\n\r\n \r\n
\r\n
\r\n <!-' + '- / icon and title -' + '->\r\n \r\n\r\n <!-' + '- message -' + '->\r\n
\r\n \r\n One more excellent iron chelator is IP6.
\n
\nPhytic acid [IP6] (inositol hexaphosphate), found naturally in seeds and bran, is nature�s most potent iron chelator (remover). [Cancer 56:717-8, 1985. Free Radical Biology Medicine 8:61-9, 1990; J Biological Chemistry 262:11647-50, 1987] It is available as an extract from rice bran, identified as IP6 in health food stores. Use of IP6 with water on an empty stomach will maximize effect. Periodic use of IP6 rice bran extract by full-grown males or post-hysterectomy/post-menopausal females, should reduce the risk of harboring mycobacteria like tuberculosis. \r\n
\r\n <!-' + '- / message -' + '->\r\n\r\n \r\n\r\n \r\n \r\n\r\n \r\n\r\n <!-' + '- sig -' + '->\r\n
\r\n __________________
\r\n .
\n- Jim
\n
\n �Men occasionally stumble over the truth, but most of them pick themselves up and hurry off as if nothing ever happened.� Sir Winston Churchill\r\n
\r\n <!-' + '- / sig -' + '->\r\n\r\n \r\n\r\n \r\n\r\n \r\n\r\n
\r\n <!-' + '- controls -' + '->\r\n \r\n \r\n \r\n Reply With Quote\r\n \r\n \r\n \r\n \r\n \r\n \r\n \r\n \r\n \r\n \r\n <!-' + '- / controls -' + '->\r\n
\r\n\r\n <!-' + '- message, attachments, sig -' + '->\r\n\r\n
\r\n\r\n\r\n<!-' + '- post 186667 popup menu -' + '->\r\n\r\n<!-' + '- / post 186667 popup menu -' + '->\r\n\r\n\r\n\r\n\r\n
\r\n \r\n
\r\n
\r\n
\r\n\r\n<!-' + '- / close content container -' + '->\r\n\r\n<!-' + '- / post #186667 -' + '->'; pd[186677] = '<!-' + '- post #186677 -' + '->\r\n\r\n <!-' + '- open content container -' + '->\r\n\r\n
\r\n
\r\n
\r\n\r\n
\r\n <!-' + '- this is not the last post shown on the page -' + '->\r\n\r\n\r\n\r\n\r\n\r\n \r\n\r\n\r\n \r\n\r\n\r\n \r\n \r\n\r\n
\r\n
\r\n �\r\n #3 �\r\n \r\n \r\n \r\n \r\n \r\n
\r\n\r\n
\r\n <!-' + '- status icon and date -' + '->\r\n Old\r\n \r\n 09-16-2011, 11:38 AM\r\n \r\n \r\n <!-' + '- / status icon and date -' + '->\r\n
\r\n
\r\n <!-' + '- user info -' + '->\r\n \r\n \r\n \r\n \r\n \r\n \r\n \r\n
Ted_Hutchinson\'s Avatar\r\n\r\n
\r\n \r\n Ted_Hutchinson\r\n Ted_Hutchinson is offline\r\n\r\n\r\n \r\n \r\n
\r\n\r\n
Lecturer
\r\n \r\n \r\n 		�\r\n\r\n
\r\n
Join Date: May 2009
\r\n \r\n \r\n
\r\n Posts: 1,783\r\n
\r\n
Blog Entries: 4
\r\n \r\n
Ted_Hutchinson will become famous soon enoughTed_Hutchinson will become famous soon enough
\r\n \r\n
\r\n
\r\n\r\n
\r\n <!-' + '- / user info -' + '->\r\n
\r\n \r\n <!-' + '- message, attachments, sig -' + '->\r\n\r\n \r\n\r\n \r\n <!-' + '- icon and title -' + '->\r\n
\r\n \r\n\r\nDefault\r\n\r\n \r\n
\r\n
\r\n <!-' + '- / icon and title -' + '->\r\n \r\n\r\n <!-' + '- message -' + '->\r\n
\r\n \r\n
\r\n
Quote:
\r\n \r\n \r\n \r\n \r\n
\r\n \r\n
\r\n Originally Posted by jfh\r\n View Post\r\n
\r\n
One more excellent iron chelator is IP6.
\r\n
\r\nPhytic acid [IP6] (inositol hexaphosphate), found naturally in seeds and bran, is nature�s most potent iron chelator (remover). [Cancer 56:717-8, 1985. Free Radical Biology Medicine 8:61-9, 1990; J Biological Chemistry 262:11647-50, 1987] It is available as an extract from rice bran, identified as IP6 in health food stores. Use of IP6 with water on an empty stomach will maximize effect. Periodic use of IP6 rice bran extract by full-grown males or post-hysterectomy/post-menopausal females, should reduce the risk of harboring mycobacteria like tuberculosis.
\r\n \r\n
\r\n
It looks like it would help protect anyone with a high risk of Parkinson\'s.\r\n
\r\n <!-' + '- / message -' + '->\r\n\r\n \r\n\r\n \r\n \r\n\r\n \r\n\r\n \r\n\r\n \r\n\r\n
\r\n <!-' + '- controls -' + '->\r\n \r\n \r\n \r\n Reply With Quote\r\n \r\n \r\n \r\n \r\n \r\n \r\n \r\n \r\n \r\n \r\n <!-' + '- / controls -' + '->\r\n
\r\n\r\n <!-' + '- message, attachments, sig -' + '->\r\n\r\n
\r\n\r\n\r\n<!-' + '- post 186677 popup menu -' + '->\r\n\r\n<!-' + '- / post 186677 popup menu -' + '->\r\n\r\n\r\n\r\n\r\n
\r\n \r\n
\r\n
\r\n
\r\n\r\n<!-' + '- / close content container -' + '->\r\n\r\n<!-' + '- / post #186677 -' + '->'; pd[186705] = '<!-' + '- post #186705 -' + '->\r\n\r\n <!-' + '- open content container -' + '->\r\n\r\n
\r\n
\r\n
\r\n\r\n
\r\n <!-' + '- this is not the last post shown on the page -' + '->\r\n\r\n\r\n\r\n\r\n\r\n \r\n\r\n\r\n \r\n\r\n\r\n \r\n \r\n\r\n
\r\n
\r\n �\r\n #4 �\r\n \r\n \r\n \r\n \r\n \r\n
\r\n\r\n
\r\n <!-' + '- status icon and date -' + '->\r\n Old\r\n \r\n 09-17-2011, 06:30 AM\r\n \r\n \r\n <!-' + '- / status icon and date -' + '->\r\n
\r\n
\r\n <!-' + '- user info -' + '->\r\n \r\n \r\n \r\n \r\n \r\n \r\n \r\n
\r\n\r\n
\r\n \r\n jfh\r\n jfh is offline\r\n\r\n\r\n \r\n \r\n
\r\n\r\n
Moderator
\r\n \r\n \r\n 		�\r\n\r\n
\r\n
Join Date: Dec 2007
\r\n
Location: Texas, USA
\r\n \r\n
\r\n Posts: 3,875\r\n
\r\n
Blog Entries: 16
\r\n \r\n
jfh will become famous soon enoughjfh will become famous soon enough
\r\n \r\n
\r\n
\r\n\r\n
\r\n <!-' + '- / user info -' + '->\r\n
\r\n \r\n <!-' + '- message, attachments, sig -' + '->\r\n\r\n \r\n\r\n \r\n <!-' + '- icon and title -' + '->\r\n
\r\n \r\n\r\nDefault\r\n\r\n \r\n
\r\n
\r\n <!-' + '- / icon and title -' + '->\r\n \r\n\r\n <!-' + '- message -' + '->\r\n
\r\n \r\n And apparently some forms of cancer have an affiliation with iron.
\n
\nCancer Inhibition By IP6
\nThis anticancer action of IP6 may be further related to mineral binding ability; IP6 by binding with Zn2+ can affect thymidine kinase activity, an enzyme essential for DNA synthesis, or remove iron, which may augment colorectal cancer.
\n
\nhttps://jn.nutrition.org/content/133/11/3778S.full\r\n
\r\n <!-' + '- / message -' + '->\r\n\r\n \r\n\r\n \r\n \r\n\r\n \r\n\r\n \r\n\r\n \r\n\r\n
\r\n <!-' + '- controls -' + '->\r\n \r\n \r\n \r\n Reply With Quote\r\n \r\n \r\n \r\n \r\n \r\n \r\n \r\n \r\n \r\n \r\n <!-' + '- / controls -' + '->\r\n
\r\n\r\n <!-' + '- message, attachments, sig -' + '->\r\n\r\n
\r\n\r\n\r\n<!-' + '- post 186705 popup menu -' + '->\r\n\r\n<!-' + '- / post 186705 popup menu -' + '->\r\n\r\n\r\n\r\n\r\n
\r\n \r\n
\r\n
\r\n
\r\n\r\n<!-' + '- / close content container -' + '->\r\n\r\n<!-' + '- / post #186705 -' + '->'; // next/previous post info pn[186665] = "186705,186667"; pn[0] = ",186665"; pn[186667] = "186665,186677"; pn[186677] = "186667,186705"; pn[186705] = "186677,186665"; // cached usernames pu[0] = guestphrase; pu[1222] = "Ted_Hutchinson"; pu[529] = "jfh"; // -->
Prev Previous Post � Next Post Next
� #1 �
Old 09-16-2011, 08:50 AM
Ted_Hutchinson's Avatar
Lecturer
 �
Join Date: May 2009
Posts: 1,783
Blog Entries: 4
Ted_Hutchinson will become famous soon enoughTed_Hutchinson will become famous soon enough
Default IRON diabetes, obesity melatonin
I've previously pointed to the free full text online paper
The Role of Impaired Mitochondrial Lipid Oxidation in Obesity that explains the role of dsyfunctional mitochondria in weight regain after dieting.
and how because melatonin has a vital role in protecting the mitochondria from iron oxidation (it acts as an iron chelator) it's got an important role. See
Melatonin Boosts Weight Loss Goals and Lowers Heart Disease Risk

To add to this story we see in this abstract how removing iron and the damage it causes helps sort out the problems caused by overweight.

Iron reduction by deferoxamine leads to amelioration of adiposity via the regulation of oxidative stress and inflammation in obese and type 2 diabetes KKAy mice.

Obviously one quick way of getting rid of excess iron is to donate blood but in the UK there is a limit to the frequency you're allowed to donate (every 4 months) So you need other strategies to keep iron low.

Iron Behaving badly
I've removed hundreds of links to references in the quote from this paper because they make it very difficult to read. The full text without the bold text to those most readily available is free full text online.
Quote:
There is also a considerable and positive role for nutrients in terms of their chelation of iron.
Indeed, polyphenolic compounds, many of which have known health benefits , are widely used as food antioxidants. There is of course considerable epidemiological evidence for the benefits of consuming fruit and vegetables that are likely to contain such antioxidants and � although possibly a minimum � this has been popularised as the 'five a day' message
Even though elements of the 'Mediterranean' diet that are considered to be beneficial are usually assumed to be so on the basis of their antioxidant capabilities many of the polyphenolic compounds (e.g. flavones, isoflavones, stilbenes, flavanones, catechins (flavan-3-ols), chalcones, tannins and anthocyanidins) so implicated may also act to chelate iron as well . This is reasonable given that many of these polyphenols and flavonoid compounds have groups such as the catechol moiety that are part of the known iron-binding elements of microbial siderophores. Examples include flavones such as quercetin, baicalin, curcumin, kolaviron , flavonol floranol xanthones such as mangiferin , morin, catechins and theaflavins as well as procyanidins and melatonin. However, the celebrated (trans-)-resveratrol molecule may act mainly via other pathways.

A considerable number of studies with non-purified dietary constituents containing the above polyphenolic components have also shown promise in inhibiting diseases in which oxidative stress is implicated. For instance in stroke and related neuronal aging and stress conditions, preventative activity can be found in blueberries, Ginkgo biloba extract , grapes , green tea , Mangifera indica extract Strawberries, spinach and Crataegus, while combinations of some these components ('protandim') have been claimed to reduce ROS levels by stimulating the production of catalase and SOD. As with pharmaceutical drugs , there are significant problems with bioavailability , although the necessary measurements are starting to come forward. There is now increasing evidence for the mechanisms with which these dietary components and related natural products and derivatives (often with anti-inflammatory, anti-mutagenic or anti-carcinogenic properties) interact with well recognised cellular signalling pathways
Reply With Quote
�

Tags
diabetes, iron, mitochondria melatonin, oxidation

� Previous Thread | Next Thread �
Thread Tools
Display Modes
Threaded Mode Threaded Mode


Similar Threads
Thread Thread Starter Forum Replies Last Post
The Swedish Approach to diabetes/obesity Ted_Hutchinson Diabetes 0 09-06-2011 01:50 AM
Pesticides linked to obesity, diabetes, metabolic syndrome. Ted_Hutchinson Nutrition 0 04-09-2011 03:16 AM
Melatonin and Diabetes liverock Diabetes 1 11-16-2010 09:00 AM
Olive Oil Extract May Help Diabetes and Obesity liverock Diabetes 1 09-13-2009 12:27 PM
Iron Levels and Diabetes Harry Hirsute Diabetes 0 08-03-2008 09:04 PM



��Useful Links

Nutrition Forum

Vitamins and Supplements

Health Insurance Forum

Mental Health Forum

Diet & Exercise

Natmed

Powered by vBulletin� Version 3.8.4
Copyright �2000 - 2013, Jelsoft Enterprises Ltd.
SEO by vBSEO �2011, Crawlability, Inc.

Site Navigation

About Us

Privacy Policy

Contact Us

Advertising