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Old 10-24-2011, 01:50 PM
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Default Never Before Seen View of Alzheimer's Disease

CHAPTER 1 ~ 12
What Is Alzheimer's Disease? (VIDEO)

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Creating memories is one of the brain's most remarkable functions.The hippocampus, located deep inside the brain, serves as the hub for making and storing memories. Located in front of the hippocampus is the amygdala, your emotional nexus. The entorhinal cortex acts as a gateway between the hippocampus and the rest of the cerebral cortex.

The nerve cell is the hub for all of the activity that occurs in the brain, and the connections between nerve cells create a living, dynamic framework for everything that we see, hear, taste, smell, touch and experience. In Alzheimer's disease, beta amyloid proteins accumulate to form large plaques between nerve cells. Eventually, the amyloid deposits block off the nerve cells from their network and cause the cells to die.

Alzheimer's is not thought to be caused by amyloid alone. Experts say that the amyloid buildup has an accomplice in another compound that interferes with nerve cell function, neurofibrillary tangles.
This is a free online interactive book that uses excellent photos and graphics to explain the terms and the processes involved in Alzheimer's progression. Some of it is video that you watch and some is interactive, you've got to use your mouse to see what parts of the screen open up.

I came across it from this link that explains more of the background
There are some things in the text that I would want to add to in places and I think it's also worth making the point that an online book like this can only present a generalized account. Inevitably will be different from the experience of someone experiencing it personally or by caring for someone with the condition.
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Old 10-24-2011, 02:42 PM
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I couldn't get the videos to play but the first one...

also note that this was funded by pfizer pharmaceutical so I dont know how much of this explanation of alzheimers is just their propaganda support the purchase of their drugs.
With then a heavy metal or a toxin or a microbe or a nutrient deficiency will NEVER be at cause and hence the best treatments or preventions may not come into awareness of the public
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Old 10-24-2011, 11:50 PM
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Originally Posted by Arrowwind09 View Post
couldn't get the videos to play but the first one...
The other chapters are interactive so you have to run your cursor over the screen to see what opens up.
There is some text below that provides more detail.

Quote:
also note that this was funded by pfizer pharmaceutical so I dont know how much of this explanation of alzheimers is just their propaganda support the purchase of their drugs.
With then a heavy metal or a toxin or a microbe or a nutrient deficiency will NEVER be at cause and hence the best treatments or preventions may not come into awareness of the public
I was reading this yesterday.
Nontraditional risk factors combine to predict Alzheimer disease and dementia
and I think maybe looking for "The Cause" of Alzheimer's or indeed expecting "The Cure" for Alzheimer's is a myth. In fact it may be misleading to think of Alzheimer's as a condition rather than an aspect of ageing brought about by the result of a lifetimes damage and the inability of our natural repair systems to cope.
Understanding the "Myth of Alzheimer's" should empower us to prevent the condition by investing more time and energy in preventing those conditions that we know increase the risk of incidence. Exercise, smoking, hypertension, diabetes, are all modifiable risk factors, ensuring we have optimum vitamin d and melatonin levels from middle age and don't get overweight will be more effective than expecting the drug companies to come up with a pill that counteracts the effects of a lifetimes consumption of junk foods (which includes everything made from wheat or corn)
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Old 10-25-2011, 04:31 AM
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Heres a take on Alzheimers from the Senior Research Scientist at MIT's Computer Science and Artificial Intelligence Laboratory.

https://www.spacedoc.com/recipe_alzheimers_disease
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Old 10-25-2011, 04:34 AM
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Well I certainly think there IS a cause. It could be multifaceted assault of bad diet and toxins... but we will never learn the truth from pfizer.
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Old 10-25-2011, 05:18 AM
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Well I certainly think there IS a cause. It could be multifaceted assault of bad diet and toxins... but we will never learn the truth from pfizer.
That's true, but it's the accumulation of many different insults to the brain that in total tip the balance and allow the Alzheimer's cascade to occur.
We therefore need to attack ALL the potential causal effects rather that implying their is no known cause and there is nothing we can do.
I've blogged on Stephanie Seneff's ideas and am sure there is plenty we can do to put her ideas into practice. We must remember the brain is mainly fat as is mylene sheath and so to protect our brains require a supply of natural saturated fat
Your body isn't going to produce any kind of cholesterol or vitamin d if the precursor molecules aren't present. Driving down cholesterol and keeping a low calorie low fat is driving the Alzheimer's Austism cancer obesity diabetes heart disease epidemics and only when health professionals understand the role of natural foods humans evolved to function best with will we get back on track.
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Old 10-25-2011, 06:32 AM
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Alzheimer's disease is triggered by the inappropriate processing of amyloid precursor protein to generate excess amounts of short peptide fragments called A-beta. For many years, the neurodegeneration associated with Alzheimer's disease was thought to be caused by the buildup of A-beta in insoluble, fibrous plaques. However, increasing suspicion now falls on smaller, soluble A-beta complexes as the toxic form of the protein, partly through their ability to induce excess calcium influx into cells, which disrupts synaptic signaling and stimulates cell death. A new study in The Journal of Cell Biology (www.jcb.org) uses high-resolution imaging to reveal that A-beta oligomers elevate calcium by forming calcium-permeable pores in the plasma membrane.

A-beta oligomers could induce calcium influx by physically disrupting the cell's outer membrane or by activating endogenous calcium channels. But studies have also shown that A-beta peptides can form calcium-permeable pores themselves in both artificial and cell membranes. A limitation of experimental techniques used to date, says Angelo Demuro, from the University of California, Irvine, is that they only monitor the activity of one or two channels at a time. In addition, different groups have obtained disparate results regarding the properties of A-beta channels using this approach.

To overcome these problems, Demuro and colleagues developed an alternative method to measure the activity of calcium channels in living cells. "We can simultaneously record the behavior of thousands of channels using an imaging technique we call optical patch-clamping," Demuro explains. In this approach, frog eggs are filled with a calcium-sensitive dye, and the researchers observe the part of the cell nearest to the cell's outer membrane. When membrane channels open to let calcium into the cell, small fluorescent flashes indicate the duration and extent of calcium influx at each individual pore.

Demuro et al. found that, just twenty minutes after A-beta oligomers were added to the eggs, they displayed flickering spots of fluorescence signifying calcium influx through single membrane channels. This influx was unlikely to be through endogenous channels activated by A-beta because frog eggs barely express calcium channels of their own. Moreover, A-beta aggregates weren't simply disrupting the eggs' membrane, as the influx was inhibited by zinc ions, which block calcium-permeable pores.

A-beta oligomers therefore form calcium-permeable channels of their own in the membrane. Demuro and colleagues characterized the properties of these pores by simultaneously imaging the activity of thousands of channels in a single membrane region. "They are all different," says Demuro. "[The pores] show a wide variety of behaviors." Most pores opened infrequently and only let in small amounts of calcium, but some opened more often and channeled large amounts of calcium into the cell. Though few in number, Demuro et al.'s measurements suggest that this latter type of pore may be largely responsible for the toxic increase in cytoplasmic calcium levels.

Differences in the properties of individual pores may be caused by differences in the number of A-beta peptides assembled into each channel, with higher-order oligomers forming the more active species of pore. "It would be nice to visualize how many A-beta peptides each pore has and whether this is related to the activity of the channel," Demuro says. If pore activity is affected by the oligomerization state of A-beta, it appears that A-beta peptides continue to assemble after their insertion into membranes, as the pores became more active as eggs were exposed to A-beta oligomers for longer periods. This increase in calcium influx over time may be related to the gradual progression of Alzheimer's symptoms.

Beyond Alzheimer's disease, Demuro et al.'s approach may help explain the pathogenesis of other neurodegenerative disorders like Parkinson's and Huntington's disease, in which misfolded and aggregated proteins have also been reported to form calcium-permeable channels.
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Old 10-25-2011, 06:46 AM
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More here on that idea
Remember the ability to clear a beta from the brain is increased in those with higher vitamin D and curcumin levels.

Another thought that comes to mind is that MAGNESIUM is a natural calcium channel blocker and MOST US adults only obtain around half the RDA for magnesium daily.
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Old 10-25-2011, 08:56 AM
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Originally Posted by liverock View Post
Heres a take on Alzheimers from the Senior Research Scientist at MIT's Computer Science and Artificial Intelligence Laboratory.

https://www.spacedoc.com/recipe_alzheimers_disease
I'm glad she includes aluminum and vaccines. Sometimes I think 'they' try to steer us away from heavy metals, toxins, and vaccines. And not just current flu shots. Dr. Blaylock says vaccines can cause damage years or decades later.
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