I was feeling like you. Just don't expect your symptoms to go steadily down. Everytime I've been treated for prostatitis the symptoms would get better, then worse and then better. After each flare during treatment there would be a period of relief with fewer symptoms. I was feeling hopeless at points too. Inflammation is part of the healing. I know it sounds weird, but your body still has to clear the infection, kills cells that are infected, and clear up mess (parts of dead bacteria) so that it can heal. This will create inflammation. If you DON'T flare up during treatment (flare typically lasted me 3-7 days) then obviously your immune system is not being activated to fight the bacteria. Which is likely within a biofilm. Antibiotics should make your symptoms a little worse. If it's a chronic infection. Acute infections are different.
Although I don't agree wih the MP. It has a good explanation of what you're feeling:
Cytokines
Related article: Innate immune response and Th1 inflammation
During immunopathology, cytokines, are elevated. Cytokines are released by the inflammatory process.
The release of cytokines appears to be essential for recovery after an infection. One study found that the cytokine TNF-alpha was essential for the proper expression of acquired specific resistance following infection with Mycobacterium tuberculosis.567 For this reason among others, TNF-alpha inhibitors, drugs which suppress the cytokine, are contraindicated for MP patients.
Endotoxins
Endotoxins, sometimes referred to as lipopolysaccharides, are proteins associated with bacteria and bacterial communities (microbiota). When these bacteria are destroyed by the innate immune system, as will happen during the MP, endotoxins are released causing a spike in symptoms known as an immunopathological reaction.
The body responds to the presence of endotoxins by producing cholesterol8 and C-reactive protein,9 among other defense mechanisms.
In immunology, the term �LPS challenge� refers to the process of exposing a subject to a lipopolysaccharide that may act as a toxin. Injecting mice with LPS has been used as models for preterm labor,10 hyperactivity,11 lung injury,12 and periodontitis,13 to cite just a few examples.
Exacerbation of symptoms
The increase in endotoxin and cytokines causes a corresponding increase in symptoms. Sometimes the symptoms are generalized and may include pain and fatigue. Other times symptoms occur at the site of infection
I was feeling like you. Just don't expect your symptoms to go steadily down. Everytime I've been treated for prostatitis the symptoms would get better, then worse and then better. After each flare during treatment there would be a period of relief with fewer symptoms. I was feeling hopeless at points too. Inflammation is part of the healing. I know it sounds weird, but your body still has to clear the infection, kills cells that are infected, and clear up mess (parts of dead bacteria) so that it can heal. This will create inflammation. If you DON'T flare up during treatment (flare typically lasted me 3-7 days) then obviously your immune system is not being activated to fight the bacteria. Which is likely within a biofilm. Antibiotics should make your symptoms a little worse. If it's a chronic infection. Acute infections are different.
Although I don't agree wih the MP. It has a good explanation of what you're feeling:
Cytokines
Related article: Innate immune response and Th1 inflammation
During immunopathology, cytokines, are elevated. Cytokines are released by the inflammatory process.
The release of cytokines appears to be essential for recovery after an infection. One study found that the cytokine TNF-alpha was essential for the proper expression of acquired specific resistance following infection with Mycobacterium tuberculosis.567 For this reason among others, TNF-alpha inhibitors, drugs which suppress the cytokine, are contraindicated for MP patients.
Endotoxins
Endotoxins, sometimes referred to as lipopolysaccharides, are proteins associated with bacteria and bacterial communities (microbiota). When these bacteria are destroyed by the innate immune system, as will happen during the MP, endotoxins are released causing a spike in symptoms known as an immunopathological reaction.
The body responds to the presence of endotoxins by producing cholesterol8 and C-reactive protein,9 among other defense mechanisms.
In immunology, the term �LPS challenge� refers to the process of exposing a subject to a lipopolysaccharide that may act as a toxin. Injecting mice with LPS has been used as models for preterm labor,10 hyperactivity,11 lung injury,12 and periodontitis,13 to cite just a few examples.
Exacerbation of symptoms
The increase in endotoxin and cytokines causes a corresponding increase in symptoms. Sometimes the symptoms are generalized and may include pain and fatigue. Other times symptoms occur at the site of infection
Yes I can understand what you mean .I have done four weeks of trim at 400mg a day. I have dropped it down to 100mg twice a day along with the other things .I go on holiday in five weeks.I will se what happens then.
We all know that sometimes you just cant see a light at the end of a tunnel.
Thanks for the encouragement folks it helps me a lot.....
"
LEXINGTON, Mass. -- Cubist Pharmaceuticals Inc. said Thursday it will move an experimental antibiotic into late-stage clinical testing as a treatment for complex infections of the urinary tract and abdomen.
The company said it will start those trials of the drug, code-named CXA-201, by the end of 2011"
Remember that one day this problem will be solved. There's a lot more pressure now for new antibiotics... which will have to work a lot better to stop resistance. So never feel like you'll have this for life.
I don't know if I've mentioned this: You need to look out for an itching or tickling sensation in the prostate and urethra. This is the feeling I had when I was being cured and things were healing. Others have reported the same thing too.
Arginine which increases Nitric oxide might increase biofilm dispersal. This would cause millions of bacteria to get released causing 'flare ups'. It's thought that natural periodic dispersal of biofilms are what causes flare ups in many bacterial infections. https://www.open-access-biology.com/b...iofilmsch9.pdf
Iwillbecured this is my new everyday reg
Vit D3
Bromelain-600 gdu/gram 5oo mg-3 times
pharmacaceutical grade L arginine -1000mg twice
quercetin-500mg also has bromelain -50mg vit c 1,250mg 3 times
allicinmax- two pills -3 times
sulfamethox/tmp 800/160 ds twice
That's great! How long will you continue the treatment for?
Some things you'll notice when treating this.
- Symptoms will cycle. They will get better, then get worse, then get better and so on...
- You might notice your semen turning yellow between 4-8 weeks
- at 4 weeks I was worse than when I started. It was the biggest flare up and clumps started showing up in my semen (like jelly or something).
- at week 4 my prostate swelled up and very slow urinary steam with weak erection
- You SHOULD start developing low grade fever or nightsweats
- Urinary flow was the last thing to improve. Once it did there was rapid improvement (around week 10-12).
- Itching sensation or tickling in the prostate seems to be indication of healing
You have to get worse before you get better. some of you might have heard of the saying. But with this disease and some others it's true. The flare ups though should not be lasting weeks. Maybe up to a week or so, and then progress.
*don't forget stretching and conscious relaxation of the perinium. Look here: https://www.freewebs.com/trydent78/ Do them morning and night if you can.
That's great! How long will you continue the treatment for?
Some things you'll notice when treating this.
- Symptoms will cycle. They will get better, then get worse, then get better and so on...
- You might notice your semen turning yellow between 4-8 weeks
- at 4 weeks I was worse than when I started. It was the biggest flare up and clumps started showing up in my semen (like jelly or something).
- at week 4 my prostate swelled up and very slow urinary steam with weak erection
- You SHOULD start developing low grade fever or nightsweats
- Urinary flow was the last thing to improve. Once it did there was rapid improvement (around week 10-12).
- Itching sensation or tickling in the prostate seems to be indication of healing
You have to get worse before you get better. some of you might have heard of the saying. But with this disease and some others it's true. The flare ups though should not be lasting weeks. Maybe up to a week or so, and then progress.
*don't forget stretching and conscious relaxation of the perinium. Look here: https://www.freewebs.com/trydent78/ Do them morning and night if you can.
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Last edited by I wiil beat this; 06-27-2011 at 07:47 AM.
HarryCrumb: I've developed tendinopathies after taking cipro. To this day I can't run or play sports like I used to. I haven't taken rocephin yet (the doctor simply considered it last time).
I wish I could take levofloxacin for example, but I can't consider it unless I have no alternatives and I am in a huge lot of pain.
Iwillbecured: how did your friend beat enterococcus without quinolones?
The doctor told me that for sure E. Coli is causing problems and Enterococcus might not be causative (or maybe it was collected due to contamination).
Anyway, according to bacteria sensitivity:
E. Coli was found to be sensitive to TMP/SMX, rocephin, fosfomycin, ciprofloxacin.
Enterococcus Spp. was found to be sensitive to tetracycline, ciprofloxacin, levofloxacin, vancomycin.
Doctor wanted to prescribe Bactrim, but I pushed for doxycycline, because: a) E. Coli is usually sensitive to doxycycline. b) in case Enterococcus is also pathogenic in my case, there's a chance that doxycycline will inhibit it, consider its sensitivity to tetracycline. c) studies show that although enterococcus is sensitive to TMP/SMX in vitro, it is not in vivo, because in vivo it can incorporate exogenously produced folates.
I am on the 20th day of doxy. I've added the supplements suggested by Iwillbecured, and also I do prostate massages every day after taking the antibiotic at night.
On the first day I felt some body shivering. There was a period that I was shivering in cold every 30 seconds.
Things have been getting slowly better I think. Although it's early to tell. Some days are better others not. For example, 2 days ago I went swimming and I felt it really helped, cause yesterday I had only minimal pain in the area. However last night I had an orgasm from masturbation (this always exarcebates my symptoms a lot), and today I'm back to having pain (although not as strong as I used to have the day after doing it). And surprise surprise - as I type this, I'm sitting here feeling tingles in my pelvic region, just like Iwillbecured said.
I do hope I'm on the right track here...
I will add broccoli to my regimen and will evaluate if I should continue on doxy or change to TMP/SMX.
iwillbecured how long should i keep going with trim. If I come to a certain amount of time and don't notice improvement say 8 weeks should I stop it altogether ?
Just got these messages in my email. Will answer everything later because I'm watching the Tennis right now lol. It's great that you guys haven't given up and are still trying to get better ... and that we all help each other. The other forum was like that.. pretty cool.
iwillbecured- what do think of taking somthing that is suppose to shrink the prostate like saw pawmetto or beta sterols another ? if my quercetin-500mg also has bromelain -50mg -vit c 1,250mg should I be taking two of these three times a day or just one
lol. It's great that you guys haven't given up and are still trying to get better ... and that we all help each other. The other forum was like that.. pretty cool.
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